Results 291 to 300 of about 51,230 (302)

Antagonist binding in the rat muscarinic receptor

Computational Biology and Chemistry, 2004
A series of agonists to the rat muscarinic receptor have been docked computationally to the active site of a homology model of rat M1 muscarinic receptor. The agonists were modelled on the X-ray crystal structure of atropine, which is reported here and the docking studies are shown to reproduce correctly the order of experimental binding affinities for
José W. Saldanha, Brian S. Potter, Rex A. Palmer, Anna C. Tanczos, Brendan J. Howlin   +4 more
openaire   +1 more source

The discovery of AZD9164, a novel muscarinic M3 antagonist

Bioorganic & Medicinal Chemistry Letters, 2011
The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD.
Helen Edwards, Antonio Mete, Keith Bowers, Vince Russell, Rhonan Ford, Barry Teobald, Ian Millichip, David Donald, Eric Chevalier, Ken Grime, Katherine J. Escott   +10 more
openaire   +3 more sources

Affinitu profile of the novel muscarinic antagonist guanylpirenzepine

Life Sciences, 1990
The study reports the functional affinity of an amidino derivative of pirenzepine, guanylpirenzepine, for muscarinic receptors mediating relaxation of rat duodenum, inhibition of rabbit vas deferens twitch contraction (both receptors previously classified as M1), guinea pig negative inotropism (M2) and ileal contraction (M3).
O. Angelici, L. Giudici, E. Cereda, A. Donetti, R. Micheletti, P. Duranti, A. Schiavone   +6 more
openaire   +3 more sources

Muscarinic Receptor Subtypes and the Selectivity of Agonists and Antagonists

Pharmacology, 1988
Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology.
Nigel J. M. Birdsall, David R. Poyner, Mark Wheatley, E.K. Pedder, Carol A. M. Curtis, P. Eveleigh, Edward C. Hulme   +6 more
openaire   +3 more sources

Muscarinic Receptor Antagonists

Pulmonary Pharmacology & Therapeutics, 1999
N. Watson, R.M. Eglen
openaire   +3 more sources

THE INTERACTION OF NICOTINIC RECEPTOR ANTAGONISTS AT MUSCARINIC RECEPTORS

Clinical and Experimental Pharmacology and Physiology, 1987
SUMMARY1. The interaction of some neuromuscular blocking drugs such as gallamine, pancuronium and stercuronium with muscarinic receptors has several features which distinguish these compounds from competitive antagonists in functional and binding studies.2. They also differentiate between muscarinic receptors and may produce effects on ion channels.
openaire   +3 more sources

The Binding of Antagonists to Brain Muscarinic Receptors

Molecular Pharmacology, 1978
E C, Hulme, N J, Birdsall, A S, Burgen, P, Mehta   +3 more
openaire   +2 more sources

Darifenacin, A selective muscarinic M3 antagonist

Pharmacological Research, 1995
A.R. MacKenzie, P.E. Cross, R.A. Burges, D.T. Newgreen, P. Quinn, R.M. Wallis   +5 more
openaire   +2 more sources

Antagonists at Muscarinic Cholinergic Receptors

2017
openaire   +2 more sources

Muscarinic Cholinergic Receptor Agonists and Antagonists

2013
Michael E. Ragozzino, Holden D. Brown
openaire   +1 more source