Results 181 to 190 of about 572,756 (326)

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, Volume 45, Issue 5, Page 1407-1422, September 2025.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea‐pigs

, 1994
Chien‐Huang Lin, Gwo‐Jyh Chang, Ming‐Jai Su, Yang‐Chang Wu, Che‐Ming Teng, Feng‐Nien Ko   +5 more
openalex   +1 more source

5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria [PDF]

, 2016
Alexander, Andersson, Baxter, Berger, Birder, Blakeman, Blanco, Bschleipfer, Chapple, Gillespie, Ikeda, Imamura, Kanai, Lecci, Liang, Masunaga, Matsumoto-Miyai, Moro, Moro, Moro, Moro, Pfeiffer, Rahnama'i, Rahnama'i, Recio, Rekik, Sadananda, Sellers, Sleight, Wang   +29 more
core   +1 more source

The Clinical Significance of the Subtypes of Detrusor Overactivity: A Systematic Review

Neurourology and Urodynamics, Volume 44, Issue 7, Page 1484-1490, September 2025.
ABSTRACT Introduction Detrusor overactivity (DO) is the “occurrence of detrusor contraction(s) during filling cystometry” [7] and can be “phasic” or “terminal” [26]. The aim of this systematic review was to establish whether there is any clinical significance between the different subtypes of DO in terms of demographics, underlying pathophysiology ...
Manisha Teji, Nicholas Raison, Nicholas Faure‐Walker   +2 more
wiley   +1 more source

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

, 1990
Eleonora Kurtenbach, C.A.M. Curtis, E.K. Pedder, A. Aitken, Alona Harris, Edward C. Hulme   +5 more
openalex   +1 more source

Barriers to achieving asthma control in adults: evidence for the role of tiotropium in current management strategies

Therapeutics and Clinical Risk Management, 2019
Christine Jenkins Department of Thoracic Medicine, The George Institute for Global Health and Concord Clinical School, University of Sydney, Sydney, NSW, Australia Abstract: Despite the availability of a range of treatment options and management ...
Jenkins C
doaj  

Closing the Evidence Gap: Retrospective and Prospective Strategies to Advance Aripiprazole's Potential Benefits in Patients With Cancer

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
Elvira Meni Maria Gkrinia, Marin Golčić, Andrej Belančić   +2 more
wiley   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Profile of a fixed-dose combination of tiotropium/olodaterol and its potential in the treatment of COPD

International Journal of COPD, 2015
Sanjeevan Muruganandan,1 Lata Jayaram2,3 1Department of Respiratory and Sleep Medicine, Austin Health, 2Department of Respiratory and Sleep Medicine, Western Health, 3University of Melbourne, Melbourne, Victoria, Australia Abstract: Chronic obstructive
Muruganandan S, Jayaram L
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