Results 181 to 190 of about 578,217 (295)

Improving the Oral Efficacy of CNS Drug Candidates:  Discovery of Highly Orally Efficacious Piperidinyl Piperidine M₂ Muscarinic Receptor Antagonists

, 2002
Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu, William J. Greenlee, John W. Clader, Craig D. Boyle, James J. Kaminski, William Billard, Binch, Gordon Crosby, Vilma Ruperto, Ruth A. Duffy, Mary Cohen-Williams, Vicki L. Coffin, Kathleen Cox, Diane E. Grotz, Jean E. Lachowicz   +16 more
openalex   +1 more source

Endothelial Cell Organization Drives Distinct Agonist‐Specific Ca2+ Dynamics in Arteries and Veins

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim The endothelium regulates cardiovascular function by detecting and interpreting multiple extracellular signals from blood and surrounding tissues, even when these inputs are complex and conflicting. The major challenge faced by the endothelium is decoding this dynamic chemical environment to produce coordinated endothelial cellular ...
M. D. Lee, R. A. Clark, C. Buckley, X. Zhang, P. Uhlen, C. Wilson, J. G. McCarron   +6 more
wiley   +1 more source

The discovery of new spirocyclic muscarinic M3 antagonists

, 2010
Michael J. Stocks, Lilian Alcaraz, Andrew Bailey, Keith Bowers, David K. Donald, Helen Edwards, Fraser Hunt, Nicholas D. Kindon, Garry Pairaudeau, Jill Theaker, Daniel J. Warner   +10 more
openalex   +1 more source

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion

European Journal of Neuroscience, Volume 62, Issue 11, December 2025.
ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Maria Ciscato, Mathilde Chouvaeff, Alexandre Mourot   +2 more
wiley   +1 more source

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

Muscarinic Ca2+ responses resistant to muscarinic antagonists at perisynaptic schwann cells of the frog neuromuscular junction

Journal of Physiology, 1997
R. Robitaille, Babak S. Jahromi, M. Charlton   +2 more
semanticscholar   +1 more source

Efficacy of Open‐Ended Urinary Catheters in Preventing Catheter‐Related Bladder Discomfort: A Randomized Controlled Trial

International Journal of Urology, Volume 32, Issue 12, Page 1819-1826, December 2025.
ABSTRACT Objective Catheter‐related bladder discomfort (CRBD) is a common postoperative complication following urological procedures, causing significant distress and reducing patient satisfaction. Although pharmacological interventions have been investigated, a more definitive approach is warranted.
Kohei Kobatake, Keisuke Goto, Tomoya Hatayama, Miki Naito, Kenshiro Takemoto, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata   +10 more
wiley   +1 more source

Lead Generation Using Pharmacophore Mapping and Three-Dimensional Database Searching:  Application to Muscarinic M₃ Receptor Antagonists

, 1999
David P. Marriott, Iain G. Dougall, Premji Meghani, Yujiang Liu, Darren R. Flower   +4 more
openalex   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

Tiotropium, a Novel Muscarinic M3 Receptor Antagonist, Improved Symptoms of Chronic Obstructive Pulmonary Disease Complicated by Chronic Heart Failure

, 2006
Mahoto Kato, Kazuo Komamura, Masafumi Kitakaze   +2 more
openalex   +2 more sources