Results 181 to 190 of about 42,993 (314)

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, Volume 183, Issue 9, Page 2123-2138, May 2026.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Evening administration of long-acting muscarinic antagonists in COPD - a randomized controlled trial. [PDF]

BMC Pulm Med
Sivapalan P, Rømer V, Jordan A, Johansen ND, Pareek M, Modin D, Mathioudakis AG, Vestbo J, Vognsen AK, Eklöf J, Hurst JR, Klausen TW, Biering-Sørensen T, Jensen JS.   +13 more
europepmc   +1 more source

Involvement of Ca2+ Signaling in the Synergistic Effects between Muscarinic Receptor Antagonists and β2-Adrenoceptor Agonists in Airway Smooth Muscle [PDF]

, 2016
Kentaro Fukunaga, Hiroaki Kume, Tetsuya Oguma, Wataru Shigemori, Yuji Tohda, Emiko Ogawa, Yasutaka Nakano   +6 more
openalex   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, Volume 183, Issue 10, Page 2360-2375, May 2026.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Cardiovascular safety of revefenacin, a once-daily, lung-selective, long-acting muscarinic antagonist for nebulized therapy of chronic obstructive pulmonary disease: Evaluation in phase 3 clinical trials

, 2019
James F. Donohue, Gregory Feldman, Sanjay Sethi, Chris N. Barnes, Srikanth Pendyala, David L. Bourdet, Glenn Crater   +6 more
openalex   +1 more source

Long‐acting muscarinic antagonist + long‐acting beta agonist versus long‐acting beta agonist + inhaled corticosteroid for COPD: A systematic review and meta‐analysis [PDF]

, 2015
Nobuyuki Horita, Naoki Miyazawa, Koji Tomaru, Miyo Inoue, Takeshi Kaneko   +4 more
openalex   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

In vivo and in vitro pharmacological characterization of SVT‐40776, a novel M ₃ muscarinic receptor antagonist, for the treatment of overactive bladder [PDF]

, 2009
C. Salcedo, Sandra de Davalillo, Joan Cabellos, Candela Lagunas, Dolors Balsa, Sofía Pérez‐del‐Pulgar, M. Ballarín, A. Pascual Fernández   +7 more
openalex   +1 more source

The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo‐controlled, crossover study

Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.
Abstract Background Inhaled saline may improve mucus transport in respiratory diseases, for example, cystic fibrosis. This randomised, placebo‐controlled, crossover study examined the effect of inhaled dry NaCl on mucociliary clearance in patients with chronic obstructive pulmonary disease (COPD). Methods Twenty‐five patients with GOLD stage I‐III COPD
Rie Skovly Thomsen, Clara Mikkelsen, Naja Enevold Olsen, Hrefna Sæunn Einarsdóttir, Mohamed Attauabi, Ronan M. G. Berg, Henrik Harboe, Jann Mortensen   +7 more
wiley   +1 more source

Possible antagonistic effects of the TRPC4 channel blocker ML204 on M₂ and M₃ muscarinic receptors in mouse ileal and detrusor smooth muscles and atrial myocardium

, 2018
Firoj Alom, Masumi MIYAKAWA, Hayato Matsuyama, Hiroshi Nagano, Yasuyuki Tanahashi, Toshihiro Unno   +5 more
openalex   +2 more sources