Results 201 to 210 of about 22,691 (214)
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Identification and characterization of m4 selective muscarinic antagonists
Bioorganic & Medicinal Chemistry Letters, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Roy D. Schwarz +5 more
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A study of muscarinic receptor heterogeneity with weak antagonists
European Journal of Pharmacology, 1976A study of heterogeneity among muscarinic receptors was carried out with new rigid molecules, comprising structures in the fused quinuclidine-valerolactone, quinuclidine-cyclohexenone, quinuclidine-cyclohexanone and quinuclidine-cyclohexane derivatives.
Abraham Fisher +4 more
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Muscarinic Receptor Subtypes and the Selectivity of Agonists and Antagonists
Pharmacology, 1988Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology.
Nigel J. M. Birdsall +6 more
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The discovery of AZD9164, a novel muscarinic M3 antagonist
Bioorganic & Medicinal Chemistry Letters, 2011The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD.
Helen Edwards +10 more
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Affinitu profile of the novel muscarinic antagonist guanylpirenzepine
Life Sciences, 1990The study reports the functional affinity of an amidino derivative of pirenzepine, guanylpirenzepine, for muscarinic receptors mediating relaxation of rat duodenum, inhibition of rabbit vas deferens twitch contraction (both receptors previously classified as M1), guinea pig negative inotropism (M2) and ileal contraction (M3).
O. Angelici +6 more
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Antagonist binding in the rat muscarinic receptor
Computational Biology and Chemistry, 2004A series of agonists to the rat muscarinic receptor have been docked computationally to the active site of a homology model of rat M1 muscarinic receptor. The agonists were modelled on the X-ray crystal structure of atropine, which is reported here and the docking studies are shown to reproduce correctly the order of experimental binding affinities for
José W. Saldanha +4 more
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Muscarinic Receptor Antagonists
Pulmonary Pharmacology & Therapeutics, 1999N. Watson, R.M. Eglen
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THE INTERACTION OF NICOTINIC RECEPTOR ANTAGONISTS AT MUSCARINIC RECEPTORS
Clinical and Experimental Pharmacology and Physiology, 1987SUMMARY1. The interaction of some neuromuscular blocking drugs such as gallamine, pancuronium and stercuronium with muscarinic receptors has several features which distinguish these compounds from competitive antagonists in functional and binding studies.2. They also differentiate between muscarinic receptors and may produce effects on ion channels.
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The Binding of Antagonists to Brain Muscarinic Receptors
Molecular Pharmacology, 1978E C, Hulme +3 more
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Darifenacin, A selective muscarinic M3 antagonist
Pharmacological Research, 1995A.R. MacKenzie +5 more
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