Results 231 to 240 of about 687,004 (308)

Muscarinic Antagonists for Myopia Control

1998
Previous nonsurgical treatment of myopia using optical and pharmaceutical agents has not allowed an unequivocal consensus. Such studies must be based on the natural history of myopia progression, accurate biometric measurements, and randomized clinical trials.
Sek-Jin Chew, Sek-Tien Hoh, Jenny Tan, Hong-Ming Cheng   +3 more
openaire   +1 more source

Allosteric antagonists of the muscarinic acetylcholine receptor

Biochemical Pharmacology, 1991
For the most part, the interaction of these selective antagonists with muscarinic receptors has been interpreted in the context of simple competitive bimolecular reaction which obeys the law of mass action. In fact, the use of selective antagonists as a pharmacological tool to identify receptor types and subtypes is based on this premise.
N H, Lee, E E, el-Fakahany
openaire   +2 more sources

Structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors.

Molecular Pharmacology, 1992
The five muscarinic receptors (m1-m5), although structurally closely related, can be distinguished pharmacologically by the use of subtype-selective ligands.
J. Wess, D. Gdula, M. Brann
semanticscholar   +1 more source

Aprophit: An irreversible antagonist for muscarinic receptors

Biochemical Pharmacology, 1990
The development of selective irreversible ligands has proven to be an invaluable technique for the isolation, purification and characterization of many receptor proteins. An isothiocyanato-derivative of the muscarinic antagonist aprophen was synthesized and evaluated as a potential irreversible ligand for muscarinic receptors.
A H, Newman, J, Covington, M, Oleshansky, B W, Jackson, B A, Weissman, H, Leader, P K, Chiang   +6 more
openaire   +2 more sources

Muscarinic autoreceptors are differentially affected by selective muscarinic antagonists in rat hippocampus

Neurochemistry International, 1989
The effects of atropine, pirenzepine and AF-DX 116 on the high K(+)-evoked release of endogenous ACh from rat hippocampal slices were compared. As expected, atropine in concentrations of 10(?5) and 10(?6)M increased the release of acetylcholine, to 128 and 157% of the control value, respectively. While AF-DX 116 was also able to increase the release to
K, Gulya, D, Budai, P, Kása
openaire   +2 more sources

Muscarinic antagonists induce different receptor conformations in rat adenohypophysis.

Molecular Pharmacology, 1983
We have employed a method based on ligand competition experiments, which is capable of detecting interactions among ligand-occupied binding sites, to study the interactions between rat adenohypophysis muscarinic receptors occupied by several muscarinic ...
Y. Henis, M. Sokolovsky
semanticscholar   +1 more source

Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors.

Journal of Pharmacology and Experimental Therapeutics, 1987
In the present study we investigated the nature of the muscarinic receptors present in the hippocampus, sympathetic ganglia, atria and salivary glands of the rat.
H. Doods, M. Mathy, D. Davidesko, K. J. Charldorp, A. Jonge, P. A. Zwieten   +5 more
semanticscholar   +1 more source

[Antianaphylactic effects of muscarinic antagonists].

Eksperimental'naia i klinicheskaia farmakologiia, 2010
The study was carried out on color guinea pigs, in which anaphylactic shock was induced by sensitizing and challenging doses of normal horse serum (HS). Administration of atropine, ipratropium, or ipratropium in combination with neostigmine led to reduction of sensitizing effect of HS: anaphylactic index was decreased up to (2.2 - 2.4) +/- 0.1 ...
G I, Nezhinskaia, A L, Vladykin, N S, Sapronov   +2 more
openaire   +1 more source

Benzylidene ketal derivatives as M2 muscarinic receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2000
Benzylidene ketal derivatives were investigated as selective M2 receptor antagonists for the treatment of Alzheimer's disease. Compound 10 was discovered to have subnanomolar M2 receptor affinity and 100-fold selectivity against other muscarinic receptors. Also, 10 demonstrated in vivo efficacy in rodent models of muscarinic activity and cognition.
C D, Boyle, S, Chackalamannil, L Y, Chen, S, Dugar, P, Pushpavanam, W, Billard, H, Binch, G, Crosby, M, Cohen-Williams, V L, Coffin, R A, Duffy, V, Ruperto, J E, Lachowicz   +12 more
openaire   +2 more sources

Muscarinic Receptor Antagonists

Pulmonary Pharmacology & Therapeutics, 1999
N, Watson, R M, Eglen
openaire   +2 more sources