Results 231 to 240 of about 578,217 (295)
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Long-acting muscarinic antagonists
Expert Review of Clinical Pharmacology, 2015Chronic obstructive pulmonary disease (COPD) is a major cause of death and disability worldwide. Inhaled bronchodilators are the mainstay of COPD pharmacological treatment. Long-acting muscarinic antagonists (LAMAs) are a major class of inhaled bronchodilators.
A. Melani
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Muscarinic Receptor Antagonists.
Handbook of Experimental Pharmacology, 2016Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
M. Matera, M. Cazzola
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Muscarinic receptor antagonists for the treatment of chronic obstructive pulmonary disease
Expert Opinion on Pharmacotherapy, 2014 M. Matera, P. Rogliani, M. Cazzola
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Long‐acting muscarinic antagonists and small airways in asthma: Which link?
Allergy. European Journal of Allergy and Clinical Immunology, 2021Involvement of small airways, those of
M. Cazzola, L. Calzetta, M. Matera
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Selective Muscarinic Receptor Agonists and Antagonists
Pharmacology & Toxicology, 1996Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
R M, Eglen, N, Watson
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Design and synthesis of a fluorescent muscarinic antagonist
Bioorganic & Medicinal Chemistry Letters, 2008The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high ...
Lyn H, Jones +5 more
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Muscarinic receptor antagonists for overactive bladder
BJU International, 2007From time to time we publish a full review of drugs that are available for the treatment of common conditions. In this issue, the review is written by two of the leading authorities in the world, Paul Abrams and Karl‐Erik Andersson, on the topic of overactive bladder and antimuscarinic agents.
Paul, Abrams, Karl-Erik, Andersson
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Selective muscarinic receptor antagonists
Trends in Pharmacological Sciences, 1984to ex- plain the anomalous binding of cholin- ergic agonists to brain receptors~ were later demonstrated with the seEective muscarinic antagonist, pirenzepine 2. Interestingly, the search for selective antagonists, which usually follows the acceptance of a concept, antedated by many years the notion of heterogeneity of rmecarinic receptors. Intuitively
R. Hammer, A. Giachetti
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Quinidine as a muscarinic antagonist: A structural approach
Journal of Pharmaceutical Sciences, 1992The synthesis, spectroscopic characteristics, and single-crystal X-ray structural analysis of quitenidine methyl ester monohydrate, a derivative of the muscarinic antagonist quinidine, are presented. Quitenidine methyl ester monohydrate (C20H24N2O4.H2O) crystallizes in the orthorhombic space group P2(1)2(1)2(1), with a = 16.69(3) A, b = 12.46(2) A, c =
M, Ciechanowicz-Rutkowska +3 more
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Aprophit: An irreversible antagonist for muscarinic receptors
Biochemical Pharmacology, 1990The development of selective irreversible ligands has proven to be an invaluable technique for the isolation, purification and characterization of many receptor proteins. An isothiocyanato-derivative of the muscarinic antagonist aprophen was synthesized and evaluated as a potential irreversible ligand for muscarinic receptors.
A H, Newman +6 more
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