Results 241 to 250 of about 556,376 (281)

MUSCARINIC RECEPTOR ANTAGONISTS IN THE TREATMENT OF OVERACTIVE BLADDER

BJU International, 2000
ABSTRACTA wealth of clinical evidence supports the view that muscarinic receptor antagonists are effective in the treatment of overactive bladder. However, treatment‐limiting adverse effects such as dry mouth, constipation, and blurred vision have restricted the usefulness of previously available agents, such as oxybutynin.
openaire   +4 more sources

Role of muscarinic receptor antagonists in urgency and nocturia

BJU International, 2005
The overactive bladder (OAB) syndrome is defined as urgency, with or without urgency incontinence, usually accompanied by frequency and nocturia. Muscarinic receptor antagonists are the most established form of treatment for OAB, but until recently their effectiveness was only confirmed for symptoms of incontinence and frequency.
Martin C. Michel, Jean J.M.C.H. de la Rosette   +1 more
openaire   +3 more sources

Muscarinic Agonists and Antagonists: Effects on the Urinary Bladder

2011
Voiding of the bladder is the result of a parasympathetic muscarinic receptor activation of the detrusor smooth muscle. However, the maintenance of continence and a normal bladder micturition cycle involves a complex interaction of cholinergic, adrenergic, nitrergic and peptidergic systems that is currently little understood.
Sellers, Donna J., Chess-Williams, Russ
openaire   +3 more sources

Identification and characterization of m4 selective muscarinic antagonists

Bioorganic & Medicinal Chemistry Letters, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Roy D. Schwarz, D.W. Moreland, C.B. Nelson, C.E. Augelli-Szafran, Juan C. Jaen, J.R. Penvose-Yi   +5 more
openaire   +5 more sources

Antagonist binding in the rat muscarinic receptor

Computational Biology and Chemistry, 2004
A series of agonists to the rat muscarinic receptor have been docked computationally to the active site of a homology model of rat M1 muscarinic receptor. The agonists were modelled on the X-ray crystal structure of atropine, which is reported here and the docking studies are shown to reproduce correctly the order of experimental binding affinities for
José W. Saldanha, Brian S. Potter, Rex A. Palmer, Anna C. Tanczos, Brendan J. Howlin   +4 more
openaire   +1 more source

A study of muscarinic receptor heterogeneity with weak antagonists

European Journal of Pharmacology, 1976
A study of heterogeneity among muscarinic receptors was carried out with new rigid molecules, comprising structures in the fused quinuclidine-valerolactone, quinuclidine-cyclohexenone, quinuclidine-cyclohexanone and quinuclidine-cyclohexane derivatives.
Abraham Fisher, Sasson Cohen, Marta Weinstock, Simon Gitter, Yona Grunfeld   +4 more
openaire   +3 more sources

The discovery of AZD9164, a novel muscarinic M3 antagonist

Bioorganic & Medicinal Chemistry Letters, 2011
The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD.
Helen Edwards, Antonio Mete, Keith Bowers, Vince Russell, Rhonan Ford, Barry Teobald, Ian Millichip, David Donald, Eric Chevalier, Ken Grime, Katherine J. Escott   +10 more
openaire   +3 more sources

Affinitu profile of the novel muscarinic antagonist guanylpirenzepine

Life Sciences, 1990
The study reports the functional affinity of an amidino derivative of pirenzepine, guanylpirenzepine, for muscarinic receptors mediating relaxation of rat duodenum, inhibition of rabbit vas deferens twitch contraction (both receptors previously classified as M1), guinea pig negative inotropism (M2) and ileal contraction (M3).
O. Angelici, L. Giudici, E. Cereda, A. Donetti, R. Micheletti, P. Duranti, A. Schiavone   +6 more
openaire   +3 more sources

Muscarinic Receptor Subtypes and the Selectivity of Agonists and Antagonists

Pharmacology, 1988
Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology.
Nigel J. M. Birdsall, David R. Poyner, Mark Wheatley, E.K. Pedder, Carol A. M. Curtis, P. Eveleigh, Edward C. Hulme   +6 more
openaire   +3 more sources

Muscarinic Receptor Antagonists

Pulmonary Pharmacology & Therapeutics, 1999
N. Watson, R.M. Eglen
openaire   +3 more sources