Results 41 to 50 of about 22,691 (214)
The Cholinergic Pathways in Inflammation: A Potential Pharmacotherapeutic Target for COPD
Frontiers in Pharmacology, 2018 In COPD, the activity of the cholinergic system is increased, which is one of the reasons for the airflow limitation caused by the contraction of airway smooth muscles.
Mitsuhiro Yamada, Masakazu Ichinose
doaj +1 more source
Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease
Therapeutics and Clinical Risk Management, 2014 Jun Zhong, Michael Roth Pneumology and Pulmonary Cell Research, Department of Biomedicine and Internal Medicine, University Hospital Basel, Basel, Switzerland Abstract: Chronic obstructive pulmonary disease (COPD) is increasing worldwide and is ...
Zhong J, Roth M
doaj
Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]
arXiv, 2020 Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv
High affinity acylating antagonists for muscarinic receptors [PDF]
Life Sciences, 1992 The muscarinic antagonists pirenzepine and telenzepine were derivatized as alkylamino derivatives at a site on the molecules corresponding to a region of bulk tolerance in receptor binding. The distal primary amino groups were coupled to the cross-linking reagent meta-phenylene diisothiocyanate, resulting in two isothiocyanate derivatives that were ...
Yishai Karton +3 more
openaire +3 more sources
Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3Muscarinic Receptor in Mice
Journal of Pharmacological Sciences, 2008 The cholinergic system plays an important role in regulation of arousal and REM sleep. In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a ...
Kousaku Ohno +2 more
doaj
BMC Urology, 2020 Background DA-8010 is a novel compound developed for the treatment of overactive bladder (OAB) and urinary incontinence. The aims of this study were to investigate the effects of DA-8010 on OAB in a rat model.
Jin Bong Choi +8 more
doaj +1 more source
Coordination on Time-Varying Antagonistic Networks [PDF]
arXiv, 2021 This paper studies coordination problem for time-varying networks suffering from antagonistic information, quantified by scaling parameters. By such a manner, interacting property of the participating individuals and antagonistic information can be quantified in a fully decoupled perspective, thus benefiting from merely directed spanning tree ...
arxiv
Application and Assessment of Deep Learning for the Generation of Potential NMDA Receptor Antagonists [PDF]
, 2020 Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have led to the synthesis of illicit drugs.
arxiv +1 more source
Journal of Pharmacological Sciences, 2011 .: In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Alteration of tumor growth
Nozomi Ami +5 more
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Inferring Synergistic and Antagonistic Interactions in Mixtures of Exposures [PDF]
arXiv, 2022 There is abundant interest in assessing the joint effects of multiple exposures on human health. This is often referred to as the mixtures problem in environmental epidemiology and toxicology. Classically, studies have examined the adverse health effects of different chemicals one at a time, but there is concern that certain chemicals may act together ...
arxiv