Results 41 to 50 of about 556,376 (281)

Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle

Journal of Pharmacological Sciences, 2007
The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized.
Hideaki Nouchi, Seri Kaeriyama, Akiko Muramatsu, Masumi Sato, Kunihiko Hirose, Nagako Shimizu, Hikaru Tanaka, Koki Shigenobu   +7 more
doaj   +1 more source

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

Advances in Pharmacological Sciences, 2009
In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve ...
Anders T. Ryberg, Ondrej Soukup, Gunnar Tobin   +2 more
doaj   +1 more source

Dementia patients have greater anti-cholinergic drug burden on discharge from hospital: A multicentre cross-sectional study

European Psychiatry, 2021
Introduction Anticholinergic medications block cholinergic transmission. The central effects of anticholinergic drugs can be particularly marked in patients with dementia.
J. Randall, A. Hook, C-M. Grubb, N. Ellis, J. Wellington, A. Hemmad, A. Zerdelis, B. Geers, B. Sykes, C. Auty, C. Vinchenzo, C. Thorburn, D. Asogbon, E. Granger, H. Boagey, J. Raphael, K. Patel, K. Bhargava, M.-K. Dolley, M. Maden, M. Shah, Q. Lee, R. Vaidya, S. Sehdev, S. Barai, S. Roche, U. Khalid, J. Harrison, D. Codling   +28 more
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Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The orthosteric binding sites of the five muscarinic acetylcholine receptor (mAChR) subtypes are highly conserved, making the development of selective antagonists challenging.
M. Korczynska, M. Clark, C. Valant, Jun Xu, Ee Von Moo, Sabine Albold, Dahlia R. Weiss, Hayarpi Torosyan, Weijiao Huang, A. Kruse, B. Lyda, L. May, Joanne Baltos, P. Sexton, B. Kobilka, A. Christopoulos, B. Shoichet, R. Sunahara   +17 more
semanticscholar   +1 more source

Muscarinic antagonist effects on executive control of attention [PDF]

The International Journal of Neuropsychopharmacology, 2009
Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic ...
Thienel, Renate, Kellermann, Thilo, Kircher, Tilo, Schall, Ulrich, Voss, Bianca, Reske, Martina, Halfter, Sarah, Sheldrick, Abigail J., Radenbach, Katrin, Habel, Ute, Shah, Nadim Jon   +10 more
openaire   +4 more sources

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Investigative Ophthalmology and Visual Science, 2018
Purpose Myopia is a refractive disorder that degrades vision. It can be treated with atropine, a muscarinic acetylcholine receptor (mAChR) antagonist, but the mechanism is unknown. Atropine may block α-adrenoceptors at concentrations ≥0.1 mM, and another
Brittany J. Carr, K. Mihara, R. Ramachandran, M. Saifeddine, N. Nathanson, W. Stell, M. Hollenberg   +6 more
semanticscholar   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes.
Hongtao Liu, J. Hofmann, I. Fish, B. Schaake, K. Eitel, A. Bartuschat, J. Kaindl, H. Rampp, A. Banerjee, H. Hübner, M. Clark, S. Vincent, J. Fisher, M. Heinrich, K. Hirata, Xiangyu Liu, R. Sunahara, B. Shoichet, B. Kobilka, P. Gmeiner   +19 more
semanticscholar   +1 more source

Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]

International Neurourology Journal, 2012
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada, Shiori Kuraoka, Ayaka Osano, Yoshihiko Ito   +3 more
doaj   +1 more source

Clinical predictors of treatment response to tiotropium add-on therapy in adult asthmatic patients: From multicenter real-world cohort data in Korea

World Allergy Organization Journal, 2022
Background: Tiotropium, a long-acting muscarinic antagonist, is recommended for add-on therapy to inhaled corticosteroids (ICS)-long-acting beta 2 agonists (LABA) for severe asthma.
Ji-Su Shim, MD, PhD, Juhae Jin, MA, Sae-Hoon Kim, MD, PhD, Taehoon Lee, MD, PhD, An-Soo Jang, MD, PhD, Chan Sun Park, MD, PhD, Jae-Woo Jung, MD, PhD, Jae-Woo Kwon, MD, PhD, Ji-Yong Moon, MD, PhD, Min-Suk Yang, MD, PhD, Jaechun Lee, MD, PhD, Jeong-Hee Choi, MD, PhD, Yoo Seob Shin, MD, PhD, Hee-Kyoo Kim, MD, PhD, Sujeong Kim, MD, PhD, Joo-Hee Kim, MD, PhD, Sang-Heon Cho, MD, PhD, Young-Hee Nam, MD, PhD, Sang-Hoon Kim, MD, PhD, So Young Park, MD, PhD, Gyu Young Hur, MD, PhD, Sang-Ha Kim, MD, PhD, Hye-Kyung Park, MD, PhD, Hyun Jung Jin, MD, PhD, Jae-Hyun Lee, MD, PhD, Jung-Won Park, MD, PhD, Ho Joo Yoon, MD, PhD, Byoung Whui Choi, MD, PhD, Young-Joo Cho, MD, PhD, Min-Hye Kim, MD, PhD, Tae-Bum Kim, MD, PhD   +30 more
doaj   +1 more source