Results 131 to 140 of about 52,654 (280)

Mechanisms reducing parasympathetic activity in chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. Using β‐adrenergic blockade to isolate parasympathetic control of heart rate at sea level and after 9‐12 days at high altitude, we investigated whether (i) chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii ...
Lauren E. Maier, Andrew Douglas, Katharine Foster, Elliott J. Jenkins, Liam D. Corr, Peter Rasmussen, James Anholm, Travis D. Gibbons, Phil N. Ainslie, Mike Stembridge, Christoph Siebenmann   +10 more
wiley   +1 more source

The Blue Delirium: Serotonin and Anticholinergic Toxicity in a 95‐Year‐Old Woman

Journal of the American Geriatrics Society, EarlyView.
Camila S. Badell, Kathleen Brodowski, Eloy F. Ruiz, Eric Tien Yen Chyn   +3 more
wiley   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

Pharmacological investigations on muscarinic and P2 receptor subtypes : pharmacological charakterisation of the stereoisomers of glycopyrronium bromide and their tertiary analogues and evaluation of the isolated guinea-pig and rat ileal longitudinal

, 2003
Die Beschäftigung mit Muskarinrezeptoren reicht bis in das vergangene Jahrhundert zurück als, in Folge der verschiedenen Wirkungen des Neurotransmitters Acetylcholin, einerseits Nikotin- und andererseits Muskarinrezeptoren sowie deren Subtypen entdeckt ...
Czeche, Sittah
core  

Effects of Transcutaneous Electrical Nerve Stimulation, Electrical Muscle Stimulation, Exercise and Heat on Back Pain—A Randomized Controlled Clinical Exploratory Trial

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background This randomized controlled study compared different forms of therapy for chronic back pain. Methods Seventy‐nine patients with chronic back pain with a duration of symptoms of more than 6 months were included in the study and randomly assigned to one of four therapy groups (a) sports therapy with a focus on strength training (SG ...
Thorsten Schmidt, Sonja Kossiski, Hanna Kornprobst, Laura von Levern, Dominik M. Schulte, Manon Sendel, Ralf Baron, Janne Gierthmühlen   +7 more
wiley   +1 more source

Cleomin Exerts Acute Antinociceptive Effects in Mice via GABA_B and Muscarinic Receptors. [PDF]

Pharmaceuticals (Basel), 2023
Opretzka LCF, Viana MDM, de Lima AA, de Souza TA, Scotti MT, Tavares JF, da Silva MS, Soares MBP, Villarreal CF.   +8 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Selective Activation of M₁ Muscarinic Receptors Attenuates Human Colon Cancer Cell Proliferation. [PDF]

Cancers (Basel), 2023
Sundel MH, Sampaio Moura N, Cheng K, Chatain O, Hu S, Drachenberg CB, Xie G, Raufman JP.   +7 more
europepmc   +1 more source

Prehospital Use of Non‐Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background In‐hospital use of non‐invasive ventilation improves outcomes in patients with acute respiratory failure caused by acute exacerbation of chronic obstructive pulmonary disease. Prehospital use of non‐invasive ventilation is uncommon due to diagnostic uncertainty and logistical constraints.
Jesper H. Brendel, Lars W. Andersen, Søren H. Skaarup, Thomas Dissing, Anders Gunnar Nielsen, Nikolaj F. Milandt, Ulrick S. Espelund, Lisa F. Irion, Lone R. Mortensen, Kim M. Larsen, Jens Aage K. Petersen   +10 more
wiley   +1 more source

Keratinocyte Muscarinic Acetylcholine Receptors: Immunolocalization and Partial Characterization

, 1995
We have reported previously that human keratinocytes synthesize and secrete acetylcholine and that muscarinic cholinergic drugs have effects on keratinocyte proliferation, adhesion, and migration.
Grando, S. A., Zelickson, Brian D., Grando, Sergei A., Bigliardi, Paul L., Wendelschafer-Crabb, G., Wendelschafer-Crabb, Gwen, Kennedy, William R., Weinshenker, Donald, Dahl, Mark V., Kist, D. A., Zelickson, B. D., Dahl, M. V., Weinshenker, D., Bigliardi, P. L., Kennedy, W. R., Kist, David A.   +15 more
core   +1 more source