Results 121 to 130 of about 43,735 (227)

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Spexin disrupts migrating myoelectric complex in the rat small intestine: The role of galanin-2 and muscarinic receptors. [PDF]

Pflugers Arch
Saltık ÖD, Balcı H, Abdullahoğlu R, Bozkurt A.   +3 more
europepmc   +1 more source

Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner . [PDF]

J Pharmacol Exp Ther, 2023
Nunes EJ, Kebede N, Haight JL, Foster DJ, Lindsley CW, Conn PJ, Addy NA.   +6 more
europepmc   +1 more source

Chemical Profiles, Pharmacological Insights, and In Silico Studies of Antidesma montanum Blume: An Experimental and Computer‐Aided Approach

eFood, Volume 7, Issue 4, August 2026.
Antidesma montanum, an edible wild plant, shows notable nutraceutical and pharmacological potential. Methanol extract profiling (GC–MS) identified bioactive metabolites. In vitro, in vivo, and in silico studies demonstrated significant antidiabetic, anthelmintic, anxiolytic, antidepressant, and antidiarrheal activities, supported by strong molecular ...
Naureen Banu, Najmul Alam, Sadia Farid Jhuma, Mohammad Nazmul Islam, Shady A. Alghazali, Md Abdul Awal, Sanjida Islam, Hafsa Siddiqua, Shafinaz Nur, Md. Sohel Rana   +9 more
wiley   +1 more source

Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium. [PDF]

R Soc Open Sci, 2022
Claßen R, Pouokam E, Wickleder M, Diener M, Mattern A.   +4 more
europepmc   +1 more source

Parasympathetic Tone Selectively Modulates Electrogram Fragmentation and Spectral Properties in Right Atrial Ganglionated Plexi

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Electrogram fragmentation and spectral EGMs features in GPs area are selectively modulated by parasympathetic tone, as demonstrated by high‐density right atrial mapping before and after vagal blockade. EGMs, bipolar atrial electrograms; GPs, ganglionated plexi; RA, right atrium.
Andrea Giomi, Andrea Bernardini, Alessandro Paoletti Perini, Margherita Padeletti, Cristiano Salvatore Zaccaria, Federica Michelotti, Umberto Signorini, Rossella Marcucci, Massimo Milli   +8 more
wiley   +1 more source

Striatal M₄ muscarinic receptors determine the biological rhythm of activity, with a supportive role of M₁ muscarinic receptors. [PDF]

Front Pharmacol
Janisova K, Uhlirova M, Forczek S, Myslivecek J.   +3 more
europepmc   +1 more source

Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. [PDF]

Proc Natl Acad Sci U S A, 2023
Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A.   +5 more
europepmc   +1 more source

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1048-1060, August 2026.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors. [PDF]

Sci Rep
Kirchhofer SB, Jelinek V, Klingelhöfer K, Krett AL, Bünemann M.   +4 more
europepmc   +1 more source