Results 141 to 150 of about 52,654 (280)
Acta Physiologica, Volume 242, Issue 7, July 2026.ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa +2 more
wiley +1 more source
A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation
Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner +4 more
wiley +2 more sources
Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction. [PDF]
Mol Neurobiol, 2023 Tomàs J +9 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim +5 more
wiley +1 more source
Muscarinic receptors: from clinic to bench to clinic. [PDF]
Trends Pharmacol Sci, 2022 Foster DJ.
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control
The Journal of Physiology, EarlyView.
Richard J. A. Wilson +1 more
wiley +1 more source
Equine Veterinary Education, Volume 38, Issue 7, Page e406-e411, July 2026.Summary An uncommon complication following prosthetic laryngoplasty was reported in a 4‐year‐old Andalusian mare. The mare was presented with a previously diagnosed left‐sided recurrent laryngeal neuropathy, after initial evaluation the mare underwent ventriculocordectomy and prosthetic laryngoplasty.
J. L. Sanclemente +2 more
wiley +1 more source
Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva +3 more
wiley +1 more source