Results 141 to 150 of about 43,735 (227)

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in <i>Saccharomyces cerevisiae</i>. [PDF]

Microb Cell
Cirigliano A, Amelina A, Passarini E, Ricelli A, Balasco N, Mori M, Botta B, De Stefano ME, Papotto C, Guerriero C, Tata AM, Rinaldi T.   +11 more
europepmc   +1 more source

Chemogenetic Activation of G12 Signaling Thickens the Epidermis With Enhanced Barrier Function

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
In this study, we investigated the role of G12 signaling in the epidermis using a keratinocyte‐specific chemogenetic approach. Activation of G12 signaling promoted keratinocyte differentiation and enhanced epidermal barrier function by upregulating filaggrin, claudin‐1, and ceramide.
Nozomi Kamakura, Natsumi Hirai, Kaito Arai, Yaxin Du, Toshiaki Kogame, Yusuke Ohno, Akio Kihara, Kenji Kabashima, Asuka Inoue   +8 more
wiley   +1 more source

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors. [PDF]

Nat Commun
Zhong Y, Tao H, Zhang Y, He B, Jiao H, Wang D, Teng M, Hu H, Guo Q, Tao Y.   +9 more
europepmc   +1 more source

Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases. [PDF]

Sci Rep, 2022
Lenina OA, Petrov KA.
europepmc   +1 more source

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Delirium is a frequent complication in comatose Out‐of‐Hospital Cardiac Arrest (OHCA) survivors requiring postresuscitation intensive care and is associated with higher mortality and longer hospitalization. Despite this, there is no established pharmacologic strategy for delirium prevention in OHCA survivors.
Benedikte Liebetrau, Anders M. Grejs, Martin A. S. Meyer, Lars P. K. Andersen, Sören Möller, Simon Mølstrøm, Jacob E. Møller, Henrik Schmidt, Steffen Christensen, Jesper Kjærgaard, Christian Hassager, Bodil S. Rasmussen, Jo B. Andreasen   +12 more
wiley   +1 more source

Muscarinic Receptors and Alzheimer's Disease: New Perspectives and Mechanisms. [PDF]

Curr Issues Mol Biol
Monaco M, Trebesova H, Grilli M.
europepmc   +1 more source

Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury. [PDF]

Front Pharmacol, 2022
Tong LY, Deng YB, Du WH, Zhou WZ, Liao XY, Jiang X.   +5 more
europepmc   +1 more source

Altered Functional Connectivity in the Reward Circuit in Betel Quid‐Dependent Chewers

Addiction Biology, Volume 31, Issue 8, August 2026.
Resting‐state fMRI identified abnormal functional connectivity within the reward circuit in individuals with betel quid dependence, involving the ventral striatum, prefrontal cortex, posterior cingulate cortex and thalamus. Reduced connectivity between the thalamus and posterior cingulate cortex was related to dependence severity and BQ dosage.
Yuegui Cao, Sisi Chen, Jiayu Li, Lingyu Kong, Jincheng He, Fulai Yuan, Jing He, Xueling Zhu   +7 more
wiley   +1 more source

Development of Mutant M₃ Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins. [PDF]

Biochemistry
Meister J, Wanka L, Perry-Hauser NA, Liu L, Iverson TM, Gurevich VV, Beck-Sickinger AG, Kruse AC, Wess J.   +8 more
europepmc   +1 more source

Postjunctional M2 Muscarinic Receptors Augment Neurally Mediated Cholinergic Contractions of Murine Airway Smooth Muscle. [PDF]

Function (Oxf), 2022
Ward SM.
europepmc   +1 more source