Results 151 to 160 of about 43,735 (227)

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Unravelling the Role of Post-Junctional M2 Muscarinic Receptors in Cholinergic Nerve-Mediated Contractions of Airway Smooth Muscle. [PDF]

Int J Mol Sci
Ghosh S, Alkawadri T, Hollywood MA, Thornbury KD, Sergeant GP.   +4 more
europepmc   +1 more source

Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors. [PDF]

BMC Complement Med Ther, 2021
Tey SL, Li CY, Lin LW, Chang LC, Chen YL, Chang FR, Yang SN, Tsai CC.   +7 more
europepmc   +1 more source

Decoding Brain Development and Function Through GABAergic Inhibitory Neurons

European Journal of Neuroscience, Volume 64, Issue 3, August 2026.
Interneuron subtype specification occurs case by case. Whereas some interneurons are specified very early, at the progenitor level, other interneurons develop final features during migration into the migratory stream or upon integration into specific cortical layers. The concept that interneuron specification can be significantly influenced by external
Renata Batista‐Brito, Christian Mayer, Mercedes Paredes, Carla G. Silva   +3 more
wiley   +1 more source

Muscarinic receptors mediate motivation via preparatory neural activity in humans. [PDF]

Elife
Grogan JP, Raemaekers M, van Swieten MMH, Green AL, Gillies MJ, Manohar SG.   +5 more
europepmc   +1 more source

Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques. [PDF]

Behav Neurosci, 2021
LaFlamme EM, Malkova L, Forcelli PA.
europepmc   +1 more source

Adverse outcomes between VMAT2 and anticholinergics in tardive dyskinesia: A target trial emulation

Psychiatry and Clinical Neurosciences, Volume 80, Issue 8, Page 637-644, August 2026.
Aim Vesicular monoamine transporter 2 (VMAT2) inhibitors have been approved for the treatment of tardive dyskinesia (TD), whereas anticholinergic agents are still widely used for this condition. This study aimed to compare the risk of major clinical adverse outcomes among patients with TD treated with VMAT2 inhibitors versus anticholinergic agents ...
Tien‐Wei Hsu, Chih‐Wei Hsu, Ping‐Tao Tseng, Yi‐Ya Fang, Chuo‐Yu Lee, Yu‐Hsuan Lin, Brendon Stubbs, Trevor Thompson, Andre F. Carvalho, Yu‐Chen Kao, Jen‐Ping Chen, Fu‐Chi Yang, Chia‐Kuang Tsai, Chih‐Sung Liang   +13 more
wiley   +1 more source

Muscarinic Receptors in Cardioprotection and Vascular Tone Regulation. [PDF]

Physiol Res
Dolejší E, Janoušková A, Jakubík J.
europepmc   +1 more source

Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors. [PDF]

JHEP Rep
Hernandez CA, Verzeroli C, Roca-Suarez AA, Farca-Luna AJ, Tonon L, Esteban-Fabró R, Pinyol R, Plissonnier ML, Chicherova I, Dubois A, Bellaud P, Seffals M, Turlin B, Fautrel A, Ichim G, Rivoire M, Passot G, Macek-Jilkova Z, Decaens T, Viari A, Testoni B, Rebouissou S, Llovet JM, Zoulim F, Parent R.   +24 more
europepmc   +1 more source

Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]

Pigment Cell Melanoma Res
Guo MS, Wu Q, Xia Y, Wu J, Wang X, Yuen GKW, Dong TT, Gao J, Tsim KWK.   +8 more
europepmc   +1 more source