Results 171 to 180 of about 52,654 (280)

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

Striatal M₄ muscarinic receptors determine the biological rhythm of activity, with a supportive role of M₁ muscarinic receptors. [PDF]

Front Pharmacol
Janisova K, Uhlirova M, Forczek S, Myslivecek J.   +3 more
europepmc   +1 more source

Fusion with Promiscuous Gα₁₆ Subunit Reveals Signaling Bias at Muscarinic Receptors. [PDF]

Int J Mol Sci, 2021
Randáková A, Nelic D, Hochmalová M, Zimčík P, Mulenga MJ, Boulos J, Jakubík J.   +6 more
europepmc   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors. [PDF]

Biomolecules
Yu W, MacKerell AD, Weber DJ, Raufman JP.   +3 more
europepmc   +1 more source

Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders. [PDF]

Biomedicines, 2022
Johnson CR, Kangas BD, Jutkiewicz EM, Bergman J, Coop A.   +4 more
europepmc   +1 more source

Genome Mining Approaches for Toxicant Discovery: A Case Study Examining Receptor Proteins for Pest Management in New Zealand

New Zealand Journal of Zoology, Volume 53, Issue 2, June 2026.
Pest control is a global challenge for agriculture and biodiversity conservation, with the use of existing vertebrate pesticides increasingly constrained by regulatory, environmental, and social pressures. There is an urgent need for safer and more species‐selective toxicants, but the development of novel vertebrate pesticides remains technically ...
Erica R. Hendrikse, Natalie J. Forsdick, Wanting Jiao, Brian Hopkins   +3 more
wiley   +1 more source

G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton

, 2005
G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitizes activated G protein-coupled receptors (GPCRs). Here, we identify ezrin as a novel non-GPCR substrate of GRK2. GRK2 phosphorylates glutathione S-transferase (GST)-ezrin, but not an
Pitcher, JA, Cant, SH
core  

Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise. [PDF]

Circ Res
Ackland GL, Hosford PS, Gutierrez Del Arroyo A, Korsak A, Machhada A, Pickard J, Gomez De La Torre GG, Stuckey DJ, Tinker A, Tobin AB, Jeon J, Wess J, Gourine AV.   +12 more
europepmc   +1 more source