Results 191 to 200 of about 52,654 (280)

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Muscarinic Receptors and Alzheimer's Disease: New Perspectives and Mechanisms. [PDF]

Curr Issues Mol Biol
Monaco M, Trebesova H, Grilli M.
europepmc   +1 more source

Postjunctional M2 Muscarinic Receptors Augment Neurally Mediated Cholinergic Contractions of Murine Airway Smooth Muscle. [PDF]

Function (Oxf), 2022
Ward SM.
europepmc   +1 more source

Restoring Septohippocampal Cholinergic Signaling Rescues Surgery‐Induced Neurogenesis and Memory Deficits in Aged Mice

Aging Cell, Volume 25, Issue 6, June 2026.
Surgery‐induced MS/vDB → DG cholinergic decline impairs hippocampal neurogenesis and memory in aged mice; galantamine‐mediated cholinergic potentiation or sustained chemogenetic activation rescues these deficits, highlighting therapeutic potential for POCD.
Lei Lei, Qingsheng Meng, Xiaoyu Hu, Jinjin Yang, Ni Du, Songxue Su, Kenji Hashimoto, Jing Cao, Jian‐jun Yang   +8 more
wiley   +1 more source

Development of Mutant M₃ Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins. [PDF]

Biochemistry
Meister J, Wanka L, Perry-Hauser NA, Liu L, Iverson TM, Gurevich VV, Beck-Sickinger AG, Kruse AC, Wess J.   +8 more
europepmc   +1 more source

Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors. [PDF]

BMC Complement Med Ther, 2021
Tey SL, Li CY, Lin LW, Chang LC, Chen YL, Chang FR, Yang SN, Tsai CC.   +7 more
europepmc   +1 more source

Fentanyl Compromises Lower‐Airway Mechanics and Naloxone Triggers a Transient Mechanical Overshoot

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the leading cause of death following opioid overdose, due to its effects on central rhythm generation, and airway and thoracic constriction. While the effects on rhythm generation have been well documented, the effects of fentanyl on airway constriction are less well understood. We tested the
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Madeline M. Johnson, Nicholas J. Burgraff   +4 more
wiley   +1 more source

Unravelling the Role of Post-Junctional M2 Muscarinic Receptors in Cholinergic Nerve-Mediated Contractions of Airway Smooth Muscle. [PDF]

Int J Mol Sci
Ghosh S, Alkawadri T, Hollywood MA, Thornbury KD, Sergeant GP.   +4 more
europepmc   +1 more source

Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques. [PDF]

Behav Neurosci, 2021
LaFlamme EM, Malkova L, Forcelli PA.
europepmc   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source