Microscopy and spectroscopy approaches to study GPCR structure and function
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl+2 more
wiley +1 more source
Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]
Guo MS+8 more
europepmc +1 more source
Potential Role for Combined Subtype-Selective Targeting of M1 and M3 Muscarinic Receptors in Gastrointestinal and Liver Diseases. [PDF]
Tolaymat M+4 more
europepmc +1 more source
Acetylcholine acts on m2‐muscarinic receptors to excite rat locus coeruleus neurones [PDF]
Terrance M. Egan, R. Alan North
openalex +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood+3 more
wiley +1 more source
Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways. [PDF]
Hasan R+10 more
europepmc +1 more source
ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]
David A. Brown, A. FORWARD, S. Marsh
openalex +1 more source
Acetylcholine contributes through muscarinic receptors to attentional modulation in V1
J. Herrero+7 more
semanticscholar +1 more source
G protein‐coupled receptor‐mediated autophagy in health and disease
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan+2 more
wiley +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison+15 more
wiley +1 more source