Results 41 to 50 of about 362,047 (272)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Skeletal Muscle, 2017 Background Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips.
Melissa L. Cox +11 more
doaj +1 more source
ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions [PDF]
arXiv, 2022 We study the high-frequency micro-mechanical response of suspensions composed by cardiac and skeletal muscle myosin by optical trapping interferometry. We observe that in low ionic strength solutions upon the addition of magnesium adenosine triphosphate (\ch{MgATP^2-}), myosin suspensions radically change their micro-mechanics properties, generating a ...
arxiv
Handling rescue therapy in myasthenia gravis clinical trials: why it matters and why you should care
Annals of Clinical and Translational Neurology, EarlyView.Abstract Myasthenia gravis (MG) clinical trials typically allow rescue therapy during follow‐up in the event of marked worsening of MG symptoms. Failure to appropriately address rescue therapy in defining treatment effects and planning statistical analyses may yield biased estimates, increase false positive rates, or decrease statistical power – all of
Justin M. Leach +3 more
wiley +1 more source
A three-dimensional model of skeletal muscle tissues [PDF]
arXiv, 2022 Skeletal muscles are living tissues that can undergo large deformations in short periods of time and that can be activated to produce force. In this paper we use the principles of continuum mechanics to propose a dynamic, fully non-linear, and three-dimensional model to describe the deformation of these tissues.
arxiv
Muscle contraction and the elasticity-mediated crosstalk effect [PDF]
Phys. Rev. E 87, 052714 (2013), 2013 Cooperative action of molecular motors is essential for many cellular processes. One possible regulator of motor coordination is the elasticity-mediated crosstalk (EMC) coupling between myosin II motors whose origin is the tensile stress that they collectively generate in actin filaments.
arxiv +1 more source
UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, EarlyView.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
wiley +1 more source
Mitochondrial Ca2+ uptake in skeletal muscle health and disease [PDF]
, 2016 Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake.
arxiv +1 more source
Activation of a muscle as a mapping of stress-strain curves [PDF]
Extreme Mechanics Letters 28 (2019): 37-42, 2019 The mathematical modeling of the contraction of a muscle is a crucial problem in biomechanics. Several different models of muscle activation exist in literature. A possible approach to contractility is the so-called active strain: it is based on a multiplicative decomposition of the deformation gradient into an active contribution, accounting for the ...
arxiv +1 more source
Mechanotransduction in skeletal muscle [PDF]
Frontiers in Bioscience, 2007 Mechanical signals are critical to the development and maintenance of skeletal muscle, but the mechanisms that convert these shape changes to biochemical signals is not known. When a deformation is imposed on a muscle, changes in cellular and molecular conformations link the mechanical forces with biochemical signals, and the close integration of ...
openaire +3 more sources