Results 41 to 50 of about 2,132,550 (292)

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations

Skeletal Muscle, 2020
Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq dataset of human muscle samples from 10 adult donors with diverse anatomical ...
Andrea J. De Micheli, Jason A. Spector, Olivier Elemento, Benjamin D. Cosgrove   +3 more
doaj   +1 more source

Skeletal Muscle Health and Cognitive Function: A Narrative Review

International Journal of Molecular Sciences, 2020
Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or
Sophia X. Sui, L. Williams, K. Holloway-Kew, N. Hyde, J. Pasco   +4 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Nicotinamide phosphoribosyltransferase (Nampt) in Lateral Hypothalamus Maintains Skeletal Muscle Functions Through Lactate‐Mediated Calcium Signalling in Male Mice

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia has become an urgent socioeconomic problem in rapidly aging societies. The pathogenesis of age‐associated sarcopenia is not fully understood and no effective therapeutic strategies have been developed to date.
Takahiro Eguchi, Keiko Kabetani, Naoki Ito   +2 more
doaj   +1 more source

Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice

Journal of Sport and Health Science
Background: Exercise is an effective intervention for obesity and type 2 diabetes, with significant physiological benefits over pharmacological interventions.
Robert J. Shute, Ryan N. Montalvo, Wenqing Shen, Yuntian Guan, Qing Yu, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

Diversification of the muscle proteome through alternative splicing

Skeletal Muscle, 2018
Background Skeletal muscles express a highly specialized proteome that allows the metabolism of energy sources to mediate myofiber contraction. This muscle-specific proteome is partially derived through the muscle-specific transcription of a subset of ...
Kiran Nakka, Claudia Ghigna, Davide Gabellini, F. Jeffrey Dilworth   +3 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes

Skeletal Muscle, 2017
Background Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2).
Amanda G. Mason, Roderick C. Slieker, Judit Balog, Richard J. L. F. Lemmers, Chao-Jen Wong, Zizhen Yao, Jong-Won Lim, Galina N. Filippova, Enrico Ne, Rabi Tawil, Bas T. Heijmans, Stephen J. Tapscott, Silvère M. van der Maarel   +12 more
doaj   +1 more source

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

Skeletal Muscle, 2023
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane.
Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates, Joseph M. Metzger   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source