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An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
Skeletal Muscle, 2023 The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and characterized, and many pathways have been elucidated throughout the years, we still lack a comprehensive ...
Anna L. Schorr +3 more
doaj +1 more source
Skeletal Muscle, 2020 Background In Duchenne muscular dystrophy (DMD), DYSTROPHIN deficiency exposes myofibers to repeated cycles of contraction/degeneration, ultimately leading to muscle loss and replacement by fibrotic tissue.
Luca Caputo +6 more
doaj +1 more source
Skeletal Muscle Health and Cognitive Function: A Narrative Review
International Journal of Molecular Sciences, 2020 Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or
Sophia X. Sui +4 more
semanticscholar +1 more source
Mechanotransduction in skeletal muscle [PDF]
Frontiers in Bioscience, 2007 Mechanical signals are critical to the development and maintenance of skeletal muscle, but the mechanisms that convert these shape changes to biochemical signals is not known. When a deformation is imposed on a muscle, changes in cellular and molecular conformations link the mechanical forces with biochemical signals, and the close integration of ...
openaire +2 more sources
Denervation does not induce muscle atrophy through oxidative stress [PDF]
, 2017 Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness.
Adamo, Sergio +10 more
core +2 more sources
The gut microbiota influences skeletal muscle mass and function in mice
Science Translational Medicine, 2019 Transplanting the gut microbiota of pathogen-free mice into germ-free mice improves skeletal muscle mass and strength. Of microbial metabolites and muscle Skeletal muscle is important not only for locomotion but also for regulating metabolic function ...
Shawon Lahiri +18 more
semanticscholar +1 more source
Implications of skeletal muscle loss for public health nutrition messages:a brief report [PDF]
, 2015 Age-related skeletal muscle loss, sarcopenia, cachexia and wider malnutrition (under nutrition) are complex in aetiology with interaction of clinical, social and economic factors.
Levy, Louis B, Welch, Ailsa A
core +1 more source
HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]
, 2018 Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
core +3 more sources
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]
, 2020 Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M +6 more
core +2 more sources
Skeletal Muscle, 2016 Background Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handling proteins, notably TDP-43 and FUS,
Sachiko Homma +4 more
doaj +1 more source