Results 31 to 40 of about 2,294,894 (319)

Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

eLife, 2018
Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis within this context remain ill-defined.
Martina Rudnicki, Ghoncheh Abdifarkosh, Emmanuel Nwadozi, Sofhia V Ramos, Armin Makki, Diane M Sepa-Kishi, Rolando B Ceddia, Christopher GR Perry, Emilie Roudier, Tara L Haas   +9 more
doaj   +1 more source

Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats

FACETS, 2022
Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes
Haiyan Wang, Amy Zheng, Edward B. Arias, Gregory D. Cartee   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Synchronizing N Release from Organic Residues: Opportunities for Integrated Management of N

The Scientific World Journal, 2001
In intensive cropping systems, mineral nitrogen (N) fertilizers represent the largest component of the N cycle because the indigenous N supply is not adequate. The requirement for mineral fertilizer may be reduced with the use of organic nutrient sources.
U. Singh, K.E. Giller, C.A. Palm, J.K. Ladha, H. Breman   +4 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Effect of Resistance Training Proximity to Failure on Muscular Adaptations and Longitudinal Fatigue in Trained Men

International Journal of Strength and Conditioning
Purpose: This study examined the effect of proximity to failure on hypertrophy, strength, and fatigue. We hypothesized strength gains would be superior in non-failure groups compared to those that include sets to momentary failure, while hypertrophy ...
Zac Robinson, Christian Macarilla, Matthew Juber, Rebecca Cerminaro, Brian Benitez, Joshua Pelland, Jacob Remmert, Thomas John, Seth Hinson, Shawn Dinh, Ethan Elkins, Laura Canteri, Caitlyn Meehan, Eric Helms, Michael Zourdos   +14 more
doaj   +1 more source

The Influence of Upper and Lower Extremity Strength on Performance-Based Sarcopenia Assessment Tests

Journal of Functional Morphology and Kinesiology, 2018
The optimal management of sarcopenia requires appropriate endpoint measures to determine intervention efficacy. While hand grip strength is a predictor of morbidity and mortality, lower extremity strength may be better associated with functional ...
Michael O. Harris-Love, Kimberly Benson, Erin Leasure, Bernadette Adams, Valerie McIntosh   +4 more
doaj   +1 more source

Muscle fatigue, bioenergetic responses and metabolic economy during load‐ and velocity‐based maximal dynamic contractions in young and older adults

Physiological Reports, 2023
We evaluated whether task‐dependent, age‐related differences in muscle fatigue (contraction‐induced decline in normalized power) develop from differences in bioenergetics or metabolic economy (ME; mass‐normalized work/mM ATP).
Liam F. Fitzgerald, Miles F. Bartlett, Jane A. Kent   +2 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source