Results 31 to 40 of about 2,151,009 (319)
eLife, 2018 Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis within this context remain ill-defined.
Martina Rudnicki +9 more
doaj +1 more source
Muscle Differentiation: A Gene for Slow Muscle? [PDF]
Current Biology, 2004 Skeletal muscle comes in two fundamental flavours, slow and fast, which determine physiological performance. Zebrafish screens have provided a handle on the molecular mechanism driving slow muscle formation. The transcriptional repressor Blimp1 has now been shown to be required in embryonic slow muscle precursor cells.
openaire +4 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Biology, 2020 The release of the endotoxin lipopolysaccharides (LPS) from gram-negative bacteria is key in the induction of the downstream cytokine release from cells targeting cells throughout the body.
Jate Bernard +4 more
doaj +1 more source
Physiological Reports, 2023 We evaluated whether task‐dependent, age‐related differences in muscle fatigue (contraction‐induced decline in normalized power) develop from differences in bioenergetics or metabolic economy (ME; mass‐normalized work/mM ATP).
Liam F. Fitzgerald +2 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Synchronizing N Release from Organic Residues: Opportunities for Integrated Management of N
The Scientific World Journal, 2001 In intensive cropping systems, mineral nitrogen (N) fertilizers represent the largest component of the N cycle because the indigenous N supply is not adequate. The requirement for mineral fertilizer may be reduced with the use of organic nutrient sources.
U. Singh +4 more
doaj +1 more source
The Influence of Upper and Lower Extremity Strength on Performance-Based Sarcopenia Assessment Tests
Journal of Functional Morphology and Kinesiology, 2018 The optimal management of sarcopenia requires appropriate endpoint measures to determine intervention efficacy. While hand grip strength is a predictor of morbidity and mortality, lower extremity strength may be better associated with functional ...
Michael O. Harris-Love +4 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source