Results 81 to 90 of about 2,151,009 (319)

Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice

Scientific Reports
Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising treatment for
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich   +8 more
doaj   +1 more source

Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval Drosophila

Biology Open, 2019
Rapamycin and other mTOR inhibitors are being heralded as possible treatments for many human ailments. It is currently being utilized clinically as an immunomodulator after transplantation procedures and as a treatment for certain forms of cancer, but it
Samuel Potter, Jacob Sifers, Emily Yocom, Sandra L. E. Blümich, Rachel Potter, Jeremy Nadolski, Douglas A. Harrison, Robin L. Cooper   +7 more
doaj   +1 more source

INTERRELATIONS OF MAGNESIUM, POTASSIUM, PHOSPHORUS, AND CREATINE IN SKELETAL MUSCLE OF MAN 1 [PDF]

, 1952
David M. Baldwin, Peter Robinson, Kenneth L. Zierler, J. L. Lilienthal   +3 more
openalex   +1 more source

THE PROSTATE MUSCLE. [PDF]

The Lancet, 1886
n ...
openaire   +3 more sources

Genetic diversity and population structure of the Taigan dog breed

FEBS Open Bio, EarlyView.
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova, Anastassiya Perfilyeva, Мamura Begmanova, Assel Zhaxylykova, Arailym Yerzhan, Kanagat Yergali, Almazbek Akunov, Marat Munarbek uulu, Anna Khamchukova, Almira Amirgaliyeva, Yelena Kuzovleva   +10 more
wiley   +1 more source

Stuart has got the PoWeR! Skeletal muscle adaptations to a novel heavy progressive weighted wheel running exercise model in C57BL/6 mice

Experimental Physiology
Murine exercise models are developed to study the molecular and cellular mechanisms regulating muscle mass. A progressive weighted wheel running model, named ‘PoWeR’, was previously developed to serve as a more translatable alternative to involuntary ...
Pieter J. Koopmans, Therin D. Williams‐Frey, Kevin A. Zwetsloot   +2 more
doaj   +1 more source

Comparación de dos dispositivos de medición de potencia y trabajo durante ejercicio de fuerza con tecnología inercial flywheel (Comparison of two power and work data acquisition systems during resistance exercise employing flywheel inertial technology)

Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación, 2016
El objetivo del presente estudio fue comparar los valores de potencia y trabajo obtenidos en tiempo real mediante los sistemas BlueBrainTM y SmartCoachTM, durante ejercicio de fuerza en una prensa de piernas equipada con tecnología inercial flywheel ...
Luis Manuel Martínez Aranda, Rodrigo Fernández Gonzalo   +1 more
doaj   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source