Results 81 to 90 of about 2,294,894 (319)

The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle

Scientific Reports
The mammalian target of rapamycin (mTOR), and specifically the mTOR complex 1 (mTORC1) is the central regulator of anabolism in skeletal muscle. Among the many functions of this kinase complex is the inhibition of the catabolic process of autophagy ...
Patrick J. Ryan, Selina Uranga, Sean T. Stanelle, Megan H. Lewis, Colleen L. O’Reilly, Jessica M. Cardin, J. William Deaver, Aaron B. Morton, James D. Fluckey   +8 more
doaj   +1 more source

Research Progress of Traditional Chinese Medicine Formula Yiqi and Muscle Building Decoction and Carcinogenic Sarcopenia [PDF]

, 2023
Jianhua Ke
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Exploring Ultrasonographic Atypical Aspects in Drug‐Resistant Multifocal Chronic Inflammatory Demyelinating Polyneuropathy

Brain and Behavior
Introduction/aims Chronic inflammatory demyelinating polyneuropathy (CIDP) and its variants are characterized by nerve enlargement (NE), particularly in the proximal segments of the median nerve (MN) and cervical roots, as assessed by ultrasound (US). NE
Angela Puma, Aurora Parrotta, Nicolas Azulay, Andra Ezaru, Michele Cavalli, Mihai Ioncea, Luisa Villa, Nicolae Grecu, Giulia Tammam, Sabrina Sacconi, Simona Maccora, Charles Raffaelli   +11 more
doaj   +1 more source

Are Force Enhancement after Stretch and Muscle Fatigue Due to Effects of Elevated Inorganic Phosphate and Low Calcium on Cross Bridge Kinetics? [PDF]

, 2020
Hans Degens, David A. Jones
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice

Scientific Reports
Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising treatment for
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich   +8 more
doaj   +1 more source

The persistence of changes in insulin sensitivity and metabolic gene expression after acute exercise in male and female mice

Current Research in Physiology
Background: Acute exercise has been suggested to increase insulin sensitivity, although the duration of the improvement may last anywhere from 4 to 72 h.
Jack H. Thompson, Alexa M. Fooskas, Erica J. Locke, Renee N. Washart, Alexandria M. Chin, Paige A.P. Ponzo, Joshua Oduwole, Nicholas DiGiuseppe, Max Matalavage, Stephen C. Kolwicz, Jr.   +9 more
doaj   +1 more source

Motor planning perturbation: muscle activation and reaction time [PDF]

, 2018
Stefan Delmas, Agostina Casamento‐Moran, Seoung Hoon Park, Basma Yacoubi, Evangelos A. Christou   +4 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source