Results 61 to 70 of about 2,965,501 (292)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The molecular dysregulation of excitation contraction coupling in patients with congenital muscle disorders [PDF]

, 2015
Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughout the muscle membrane activates muscle contraction, by releasing Ca2+ from the Sarcoplasmic Reticulum (SR).
Rokach, Ori
core   +1 more source

Concurrent HIIT and Resistance Training for Musculoskeletal Function: A Systematic Review of Neuromuscular, Morphological, and Performance Adaptations

Life
This systematic review focuses on the effect of concurrent high-intensity interval training (HIIT) and resistance training on musculoskeletal function in adult individuals.
YuWei Chang, Hsia-Ling Tai, Cheng-Long Yang, Chun-Hsien Su   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Architecture as a Way of Seeing and Learning [PDF]

, 2021
At the beginning of 2020, 66 long-term refugee camps existed along the East African Rift. Millions of young children have been born at the camps and have grown up there, yet it is unknown how their surrounding built environments affect their learning and
Elorduy, Nerea Amorós
core   +1 more source

A Sonographic and Functional Study of the Patterns of Changes in the Tibialis Anterior Muscle in Chronic Hemiplegic Patients, a Pilot Study

Biomedicines
Introduction: Chronic stroke frequently causes structural and functional impairments in the tibialis anterior (TA) muscle, leading to foot-drop and altered gait kinematics.
Daniela Poenaru, Claudia Gabriela Potcovaru, Livia Alexandra Ion, Andreea Dumitrescu, Simona Elena Savulescu, Delia Cinteza   +5 more
doaj   +1 more source

The Hamstrings: Anatomic and Physiologic Variations and Their Potential Relationships With Injury Risk

Frontiers in Physiology, 2021
The incidence and recurrence of hamstrings injuries are very high in sports, posing elevated performance and financial-related costs. Attempts to identify the risk factors involved in predicting vulnerability to hamstrings injury is important for ...
José Afonso, Sílvia Rocha-Rodrigues, Sílvia Rocha-Rodrigues, Sílvia Rocha-Rodrigues, Filipe M. Clemente, Filipe M. Clemente, Michele Aquino, Pantelis T. Nikolaidis, Hugo Sarmento, Alberto Fílter, Alberto Fílter, Jesús Olivares-Jabalera, Jesús Olivares-Jabalera, Rodrigo Ramirez-Campillo, Rodrigo Ramirez-Campillo   +14 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effect of combined plyometric and eccentric strength training on fascicle length, pennation angle and sprint performance in male sprinters

Physical Education of Students
Background and Study Aim. Neuromuscular, biomechanical, and anatomical features interact in a complicated way to determine sprint performance. Characteristics of muscle architecture, such as fascicle length and pennation angle, are important structural ...
Ajay Kumar, Shashvat Priyam Khare, Sapna Mandoli, Rishiraj Vishwakarma, Akshat Mandiwal, Shivam Gandhi   +5 more
doaj   +1 more source

Additional heads of dorsal interosseous muscle in Caucasian cadavers and their clinical significance

Sahel Medical Journal, 2013
Dorsal interossei are group of four intrinsic muscles of the hand that are of immense importance in its day-to-day functions. The finding of any variation related to these muscles is of significance from point of view of hand surgeons.
Vaishaly Kishore Bharambe, Sapna Prashant Shevde, Vatsalaswamy Puranam, Nilesh Subhash Kanaskar   +3 more
doaj   +1 more source