Results 131 to 140 of about 920,865 (221)

Lysophosphatidic acid mediates skeletal muscle fibrosis in denervation via activation of YAP/TAZ

JCI Insight
Lysophosphatidic acid (LPA) is a bioactive lipid that signals through G protein–coupled receptors (LPA1–6) and regulates multiple cellular processes, including fibrosis.
Meilyn Cruz-Soca, Adriana Córdova-Casanova, Jennifer Faundez-Contreras, Nicolás W. Martínez, Francesca Vaccaro-Rivera, Sebastián Bazaes-Astorga, Cristian Gutiérrez-Rojas, Felipe S. Gallardo, Daniela L. Rebolledo, Felipe A. Court, Jerold Chun, Carlos P. Vio, Soledad Matus, Juan Carlos Casar, Enrique Brandan   +14 more
doaj   +1 more source

iPLA ₂ β: A novel store-operated calcium entry modulator contributing to muscle dysfunction during denervation

Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a major cause of frailty and disability, with neuromuscular denervation as a key contributor.
Kara Kneuper, Holly Van Remmen, Luis Gustavo Oliveira de Sousa, Victoria Tyrrell, Jacob Brown, Elizabeth Duggan, Ashley Bell, Bo Hagy, Kenneth Humphries, Constantin Georgescu, Andy Gamez-Rico, Shylesh Bhaskaran, Hongyang Xu, Jessica Thomason, Valerie B. O’Donnell, Thomason, Jessica, Georgescu, Constantin, O’Donnell, Valerie B., Humphries, Kenneth, Brown, Jacob, Gamez-Rico, Andy, Tyrrell, Victoria, Remmen, Holly Van, Bell, Ashley, Bhaskaran, Shylesh, Kneuper, Kara, Duggan, Elizabeth, Xu, Hongyang, Sousa, Luis Gustavo Oliveira de, Hagy, Bo   +29 more
core   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Photomicrographs of transverse sections of the gastrocnemius muscle following denervation and subsequent reinnervation.

, 2013
The muscle sections of (A) immediate repair, (B) chronic denervation with sensory protection and (C) chronic denervation with mixed-nerve protection showed wide areas of larger muscle fibers among small groups of atrophied fibers.
Qing Tian Li (481325), Bao Guo Jiang (481330), Pei Xun Zhang (481326), Yu Hui Kou (481328), Jiu Xu Deng (481329), Na Han (167625), Xiao Feng Yin (481327)   +6 more
core   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of both the metaboreflex via post‐exercise circulatory occlusion and the chemoreflex via acute and chronic hypoxia increased pulmonary artery systolic pressure. Coactivation of these reflexes further increased pulmonary artery pressure in an additive manner.
Lauren E. Maier, Elliott J. Jenkins, Andrew Douglas, Jack Talbot, Alexandra Williams, Jonathan Moore, Craig D. Steinback, Liam D. Corr, Zoe H. Adams, Fabio Giuseppe Laginestra, Markus Amann, Philip N. Ainslie, Travis D. Gibbons, Mike Stembridge   +13 more
wiley   +1 more source

Adaptations of glucagon‐like peptide‐1 receptor agonist‐induced weight loss, drivers of weight regain and future directions of therapeutics

The Journal of Physiology, EarlyView.
Abstract figure legend During GLP‐1RA treatment reduced appetite and energy intake, delayed gastric emptying, decreased visceral fat mass and improved glycaemic control contribute to weight loss. After treatment cessation these benefits are partially or completely reversed, resulting in weight regain, accompanied by increased appetite and energy intake,
Camille E. M. Piguet, Rosie Nucci, Jacqueline L. Beaudry   +2 more
wiley   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

CO2 chemoreflex contributions to ventilatory long‐term facilitation

The Journal of Physiology, EarlyView.
Abstract figure legend To determine whether changes in CO2 chemoreflex sensitivity contribute to ventilatory long‐term facilitation (LTF), we tested the hypothesis that hypercapnic acute intermittent hypoxia (AIH) induces ventilatory LTF and enhances peripheral, but not central, chemoreceptor CO2 chemoreflex sensitivity.
Susan V. Cross, Elizabeth Keen, Tom E. Nightingale, Zubair Ahmed, George M. Balanos, Joseph F. Welch   +5 more
wiley   +1 more source

Non‐steady‐state modelling reveals reduced skeletal muscle protein synthesis as the primary driver of disuse‐atrophy in young, healthy females

The Journal of Physiology, EarlyView.
Abstract figure legend We used a unilateral model of divergent contractile stimuli, in which one leg was subjected to 10 days of unloading and the contralateral leg was simultaneously subjected to loading. We examined how accounting for changes in protein pool size, using steady‐state and non‐steady‐state modelling approaches, impacted rates of muscle ...
Callum J. Pufahl, Jonathan C. Mcleod, Emily J. Ferguson, Kristine Boileau, Brendan Ross, Thomas R. Tripp, Jennifer A. Wilkinson, Craig A. Simpson, Brendon J. Gurd, Chris McGlory   +9 more
wiley   +1 more source