Results 141 to 150 of about 920,865 (221)

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
María D. Girón, Manuel Manzano, Suzette L. Pereira, Antonio Reinoso, Chiara Burgio, Nora Montero‐Martin, Guillermo Jiménez‐Jiménez, Josep M. Argilés, Ricardo Rueda, José M. López‐Pedrosa, Rafael Salto   +10 more
wiley   +1 more source

Mitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca2+ Overload‐Mitophagy‐Ferroptosis Circuit

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Denervation‐induced muscle atrophy progresses during the interval between nerve injury and reinnervation, and depletion of muscle satellite cells (MuSCs) contributes to impaired functional recovery. Although mitochondrial dysfunction and impaired quality control are implicated in muscle wasting, whether excessive mitochondrial ...
Haiqi Ding, Jiagu Huang, Jiayao Zhang, Zhizhen He, Jun Luo, Zhao Lin, Linhai Yang, Yibin Su, Mingjuan Zhang, Fuli Wen, Yuan Lin, Cheng Chang, Hanhao Dai, Xuehui Ge, Jie Xu   +14 more
wiley   +1 more source

Myocytes changes and satellite cells proliferation following denervation of ALD (Anterior Latissimus Dorsi) and PLD (Posterior Latissimus Dorsi) muscles in two strains of turkey (Meleagris gallopavo)

, 2014
Morphological features and chronology of myocytes changes after denervation were studied over 35 days period in 2 heavy (HW) and light-­weight (LW) strains of 5-­week-­old male turkeys. Denervation caused progressive atrophy in posterior latissimus dorsi
Apreutese, A, Wyers, Monique, Cherel, Yan, Bakou, S, Guigand, Lydie, Apreutese, Radu   +5 more
core   +1 more source

Observations on the atrophy of denervated muscle

The Journal of Physiology, 1918
J N, Langley, M, Hashimoto
openaire   +3 more sources

S100A9 Mediates Neuroblastoma‐Associated Skeletal Muscle Atrophy via O‐GlcNAcylation Repression and Activate Mitophagy Activation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background In patients with neuroblastoma (NB), skeletal muscle atrophy is a key factor linked to poor survival and decreased long‐term quality of life. Nevertheless, there are still insufficient therapeutic methods that work, and the underlying mechanisms remain unclear.
Jianwei Lin, Yuxin Zhang, Qi Wang, Jingchun Lv, Bingqiang Han, Dapeng Jiang   +5 more
wiley   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 10, Page 977-992, December 2026.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Polyphenol dietary supplementation prevents inflammation‐induced muscle atrophy in a zebrafish (Danio rerio) model

Journal of the Science of Food and Agriculture, Volume 106, Issue 15, Page 9581-9595, December 2026.
Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso, Monica Matuozzo, Mariapina Rocco, Seyed Hossein Hoseinifar, Ghasem Ashouri, Andrea Scaloni, Marina Paolucci, Chiara D'Ambrosio, Roberta Imperatore   +8 more
wiley   +1 more source

Chronic Scrotal Content Pain: A Practical Guide to Diagnosis and Management

Trends in Urology &Men's Health, Volume 17, Issue 6, December 2026.
ABSTRACT Chronic scrotal content pain (CSCP) is a common but often poorly understood condition that presents a significant diagnostic and therapeutic challenge. The broad differential diagnosis and frequent absence of an identifiable cause can lead to repeated investigations, delayed treatment and unnecessary surgery.
Mahin Chowdhury, Mohammad Arabiyat, Ibrahim Abuelbeh, Theodora Stasinou, Peter Grice, Vaibhav Modgil, Ian Pearce   +6 more
wiley   +1 more source

Pericapsular nerve group block with phenol for non‐operative hip fracture management in patients living with frailty: a prospective multicentre cohort study

Anaesthesia, Volume 81, Issue 12, Page 1673-1685, December 2026.
Summary Introduction The incidence of hip fractures is rising with the ageing population. For patients living with severe frailty and limited life expectancy, non‐operative management is increasingly considered after shared decision‐making. Given the limited availability of long‐term analgesic options, alternative techniques are needed.
Rachel J. H. Smits, Marte I. Lommerse, Hugo H. Wijnen, Lennart G. Wasmoeth, Glenn van de Vossenberg, Gezina T. M. L. Oei, Henk J. Schuijt, Kris C. P. Vissers, Hanna C. Willems, Jan Willem Kallewaard, Selina E. I. van der Wal, the Dutch‐PENG registry collaborators, Gert R. Roukema, Dawi Van der Stap, J.S.H.A. (Seppe) Koopman, Bart P.A. Spaetgens, Renée Brüggemann, Nicole Lefel, Manon Vugts, Nikki M.F. Noorda, Vincent Van Dongen, Hidde Krot, Nicole Grupa, Daisy Hoofwijk, Léon Timmerman   +24 more
wiley   +1 more source