Results 131 to 140 of about 1,789,342 (255)

Caloric restriction and aerobic exercise differentially counteract muscle–tendon dysfunction following diet‐induced obesity in C57BL/6J mice

The Journal of Physiology, EarlyView.
Abstract figure legend Diet‐induced obesity induced fibro‐adipogenic remodelling of the muscle–tendon unit, characterized by increased fibrosis, reduced specific force, impaired relaxation kinetics, elevated hysteresis, and reduced aerobic capacity and glucose tolerance.
Leonardo Cesanelli, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Ingrida Balnyte, Polzonetti Valeria, Tomas Venckunas, Cameron Hill, Danguole Satkunskiene, Hans Degens   +9 more
wiley   +1 more source

Metabolic Syndrome Insulin Resistance is Associated with Discordant Distrbution of GLUT4 and the Insulin Receptor in Fast‐Twitch and Slow‐Twitch Muscle Fiber Types

, 2011
Metabolic Syndrome Insulin Resistance Is Associated with Discordant Distribution of GLUT4 and the Insulin Receptor in Fast-Twitch and Slow-Twitch Muscle Fiber Types We have previously shown that We have previously shown that strength training alone ...
Ramsey, Michael W., Howell, Mary E.A., Marino, Anna, McCurry, Melanie P., South, Mark A., Stuart, Charles A., Stone, Michael H.   +6 more
core   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Integrated Proteomic and Metabolomic Analysis of Muscle Atrophy Induced by Hindlimb Unloading

Biomolecules
Skeletal muscle atrophy, which is induced by factors such as disuse, spaceflight, certain medications, neurological disorders, and malnutrition, is a global health issue that lacks effective treatment.
Yuan Wang, Xi Li, Na Li, Jiawei Du, Xiaodong Qin, Xiqing Sun, Yongchun Wang, Chengfei Li   +7 more
doaj   +1 more source

β‐hydroxy‐β‐methylbutyrate improves fast‐twitch muscle function, histopathology and mitochondrial respiration in the D2.mdx dystrophic mouse

The Journal of Physiology, EarlyView.
Abstract figure legend β‐Hydroxy‐β‐methylbutyrate (HMB) enhances fast‐twitch muscle and mitochondrial function in D2.mdx mice. Male DBA/2J (wild‐type) and D2.mdx mice aged 3 or 6 months received daily β‐hydroxy‐β‐methylbutyrate (HMB; 1 mg g−1 day−1) via drinking water for 8 weeks. Fast‐twitch extensor digitorum longus (EDL) and slow‐twitch soleus (SOL)
Nicholas Giourmas, Hannah Lalunio, Memphis Calzoni, Ryan Bagaric, Craig A. Goodman, Alan Hayes   +5 more
wiley   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Noncontrast MRI Assessment of Oxygen Metabolism in Human Calf Muscles Using VSASL and ANN‐Based GESSE

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Workflow (Steps 1–4): Both MBF and MOEF maps were registered to a T2‐weighted fat‐suppressed structural image using rigid or affine transformations in 3D Slicer. The gastrocnemius, soleus, and tibialis anterior muscles were segmented in 3D volumes, and the resulting segmentations were used as masks to propagate to all parameter maps to extract regional
Congcong Fu, Hanyi Zhang, Hans‐Ulrich Kauczor, Hyungseok Jang, Sam Sedaghat, Ke Zhang   +5 more
wiley   +1 more source

Intramuscular Fat Infiltration and Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Physiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Background Intramuscular fat infiltration (IMFI) is considered to be closely associated with knee osteoarthritis (KOA); however, its overall association, muscle‐specific involvement, and clinical relevance remain unclear. Objective To quantify the association between IMFI and KOA, identify affected muscle groups, and evaluate prognostic value.
Lili Yu, Cong Chen, Guancong Zhang, Qiuchen Huang, Miao Ye, Yukiko Makihara, Yusuke Nishida   +6 more
wiley   +1 more source

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

Exercise and Autonomic Cardiovascular Function—Insights From Spinal Cord‐Injured Humans: A Narrative Review

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT The cardiovascular response to acute exercise is mediated by the autonomic nervous system (ANS) control mechanisms that modulate vascular resistance to support blood pressure and ensure adequate blood flow to active muscles. These autonomic neurocirculatory control mechanisms include a feedforward mechanism, known as central command, and three
Rasmus Kopp Hansen, Ryan Godsk Larsen, Tom E. Nightingale, Daniel D. Hodgkiss, Niels H. Secher, Stefanos Volianitis   +5 more
wiley   +1 more source