Results 111 to 120 of about 11,850 (212)

Integrated Proteomic and Metabolomic Analysis of Muscle Atrophy Induced by Hindlimb Unloading

Biomolecules
Skeletal muscle atrophy, which is induced by factors such as disuse, spaceflight, certain medications, neurological disorders, and malnutrition, is a global health issue that lacks effective treatment.
Yuan Wang, Xi Li, Na Li, Jiawei Du, Xiaodong Qin, Xiqing Sun, Yongchun Wang, Chengfei Li   +7 more
doaj   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first‐in‐class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle homeostasis, its effects on skeletal muscle ...
Yangli Ye, Diandian Qian, Ikumi Nomura, Naoki Kobayashi, Yukiko Shimizu, Tadashi Okamura, Motoharu Awazawa, Kohjiro Ueki   +7 more
wiley   +1 more source

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo   +7 more
wiley   +1 more source

Characterizing Metabolic and Compositional Heterogeneity of Calf Muscle Using CEST MRI at 3 T

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
This study used 3 T CEST MRI to characterize metabolic and compositional heterogeneity in eight healthy calf muscles, focusing on amide, PCr, rNOE, and MT contrasts. Distinct signatures emerged between deep stabilizer and superficial powerhouse muscles. Significant correlations with age, fat content, BMI, and strength (e.g., rNOE vs. strength) revealed
Huabin Zhang, Kangli Pi, Ziyan Wang, Fan Huang, Juan Wei, Patrick Liebig, Lin Chen, Yang Zhou, Yi Zhang, Varut Vardhanabhuti, Jianpan Huang   +10 more
wiley   +1 more source

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, Volume 105, Issue 2, Page 151-162, August 2026.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects

Experimental Physiology, Volume 111, Issue 8, Page 3699-3717, 1 August 2026.
Abstract The present study examined the cardiovascular, metabolic, neuromuscular and perceptual effects of low‐intensity jumping in simulated lunar gravity (∼20% bodyweight) with blood flow restriction (BFR). Fourteen healthy adults (24 ± 4 years; 1.81 ± 0.06 m; 75 ± 12 kg) completed an incremental jumping test in simulated lunar gravity (9.5° head‐up ...
Patrick Swain, Filipa Santos, Nick Caplan, Cody Latue, Billie Illingworth, Nicky Sheard, Luke Hughes   +6 more
wiley   +1 more source

Changes in palmitate- and stearate-containing glycerophospholipids in skeletal muscle during clenbuterol-induced fast-twitch fiber transition and hypertrophy. [PDF]

J Physiol Sci
Suzuki Y, Sato T, Ohuchi S, Nakashima S, Miyoshi N, Miura S.   +5 more
europepmc   +1 more source

microRNA profiles in slow and fast skeletal muscle fibers. [PDF]

Physiol Genomics
Simon L.
europepmc   +1 more source

Myosin Effects on Thin Filament Activation in Slow-Twitch Human Soleus Muscle Fibers [PDF]

Biophysical Journal, 2018
Alfredo J. Lopez-Davila, Robert Stehle, Stefan Zittrich, Birgit Piep, Faramarz Matinmehr, Andras Malnasi, Anna Rauscher, Joseph Chalovich, Theresia Kraft, Bernhard Brenner   +9 more
openaire   +1 more source