Results 91 to 100 of about 11,850 (212)

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Morphological peculiarities of neuromuscular junctions among different fiber types: Effect of exercise

European Journal of Translational Myology, 2017
The aim of our research was to examine whether there are differences in the morphology of neuromuscular junctions of different types of muscle fibers in rodents, and after their adaptation to six weeks endurance exercise training. After 5-day acclimation,
Teet Seene, Maria Umnova, Priit Kaasik
doaj   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

Molecular Metabolism
Objective: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH.
Alena Akhmetshina, Valentina Bianco, Ivan Bradić, Melanie Korbelius, Anita Pirchheim, Katharina B. Kuentzel, Thomas O. Eichmann, Helga Hinteregger, Dagmar Kolb, Hansjoerg Habisch, Laura Liesinger, Tobias Madl, Wolfgang Sattler, Branislav Radović, Simon Sedej, Ruth Birner-Gruenberger, Nemanja Vujić, Dagmar Kratky   +17 more
doaj   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Neuromuscular fatigability with repeated exercise in hypoxia: From single‐joint paradigms to sprints

The Journal of Physiology, EarlyView.
Abstract figure legend Acute hypobaric or normobaric hypoxic exposure accelerates neuromuscular fatigability during repeated exercise. Indices of peripheral and central fatigue are not different at exhaustion in mild, moderate and severe hypoxia compared with normoxia, but task failure occurs earlier.
Luca Ruggiero, Franck Brocherie, Olivier Girard, Nathan Townsend, Chris J. McNeil, Grégoire P. Millet   +5 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how 6 weeks of dynamic knee‐extensor interval training with blood flow restriction (BFR‐leg) and without (CTRL‐leg) impacts performance and its mechanisms using non‐invasive methods. Specifically, we used gold‐standard methods to assess neuromuscular function, vascular function using Doppler ultrasound, and near ...
Colin Lavigne, Valentin Mons, Clément Lemineur, Oliver Meste, Georges Lefthériotis, Grégory M. Blain   +5 more
wiley   +1 more source