Results 81 to 90 of about 11,850 (212)

In vitro and in vivo muscle mass and strength during the first week of critical illness

Intensive Care Medicine Experimental
Background Loss of muscle mass and strength is provoked by critical illness. Our primary aim was to study the development of muscle atrophy and weakness in vitro in isolated myofibers and in vivo muscle mass and in vitro muscle strength during the first ...
Wout J. Claassen, Isabel M. van Ruijven, Marloes van den Berg, Rianne J. Baelde, Alexcia Fortes Monteiro, Rajvi M. N. Balesar, Sylvia W. Hania, Donald L. van der Peet, Peter J. M. Weijs, Coen A. C. Ottenheijm, Sandra N. Stapel   +10 more
doaj   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Effects of bed rest and immobilization on intramuscular and intermuscular adipose tissue: A systematic review

Experimental Physiology, EarlyView.
Abstract Muscle disuse caused by bed rest and immobilization is associated with muscle atrophy and insulin resistance, which might be related to increases in intramuscular fat (IntraMAT) and intermuscular fat (InterMAT) accumulation. In this systematic review, we compiled evidence on the effects of bed rest and unilateral lower‐limb immobilization on ...
Konstantinos Prokopidis, Julia Margarita Reyes, Gustavo Duque   +2 more
wiley   +1 more source

Small muscle mass aerobic exercise in health and disease: Unique insights into muscle vascular and metabolic control and performance

Experimental Physiology, EarlyView.
Abstract Studies of small muscle mass exercise (SMME) have revealed that the peripheral O2 transport–utilization cascade is a dynamically regulated system in which perfusive and diffusive components can be selectively amplified, redistributed and mechanically limited depending on contraction pattern, recruitment strategy and intramuscular pressure ...
Shunsaku Koga, David C. Poole, Thomas J. Barstow, Dai Okushima, Richie P. Goulding   +4 more
wiley   +1 more source

Nuclear receptors and skeletal muscle fiber type

Journal of Physical Fitness and Sports Medicine, 2015
The contractile and metabolic properties of skeletal muscle depend on muscle fiber type composition. There are two major fiber types: type 1 fibers (slow-twitch oxidative) and type 2 fibers (fast-twitch glycolytic).
Wataru Mizunoya
doaj   +1 more source

Intermittent low‐intensity contractions cause a dissociation between maximal motor unit firing rates and changes in torque and contractile speed

Experimental Physiology, EarlyView.
Abstract The purpose was to test: (1) whether the decline in maximal motor unit (MU) firing rate is an invariable response when maximal voluntary contraction (MVC) torque is reduced following a submaximal muscle fatiguing task; and (2) whether fatigue‐induced slowing of contractile speed and firing rate decline are co‐dependent. Ten participants (three
Alexander M. Zero, Raaj A. Dudani, Jacob Fanous, Charles L. Rice   +3 more
wiley   +1 more source

Impact of lengthening velocity on the generation of eccentric force by slow-twitch muscle fibers in long stretches

Pflügers Archiv - European Journal of Physiology
AbstractAfter an initial increase, isovelocity elongation of a muscle fiber can lead to diminishing (referred to as Give in the literature) and subsequently increasing force. How the stretch velocity affects this behavior in slow-twitch fibers remains largely unexplored.
Weidner, Sven, Tomalka, André, Rode, Christian, Siebert, Tobias   +3 more
openaire   +3 more sources

Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss

Experimental Physiology, EarlyView.
Abstract Repurposing clinically approved antifibrotic agents presents a potential near‐term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We hypothesized that daily oral administration of pirfenidone, an FDA‐approved antifibrotic, would mitigate
Jessica M. Motherwell, Ondine Eken, Claudia E. Hernandez, Christopher L. Dearth, Stephen M. Goldman   +4 more
wiley   +1 more source

Twitch force in human Amyotrophic Lateral Sclerosis

Frontiers in Neurology
IntroductionThis study investigated differences in muscle twitch force between slow and fast progressors of amyotrophic lateral sclerosis (ALS) to better understand disease heterogeneity and identify potential biomarkers of disease progression ...
Laura Libonati, Chiara Cambieri, Marco Ceccanti, Federica Moret, Matteo Di Giulio, Eleonora Palma, Maurizio Inghilleri, Maurizio Inghilleri   +7 more
doaj   +1 more source

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function.
Derk H. C. Nieuwenhuijsen, Moritz Eggelbusch, Rob C. I. Wüst   +2 more
wiley   +1 more source