Results 21 to 30 of about 11,850 (212)

Mdfi Promotes C2C12 Cell Differentiation and Positively Modulates Fast-to-Slow-Twitch Muscle Fiber Transformation [PDF]

Frontiers in Cell and Developmental Biology, 2021
Muscle development requires myoblast differentiation and muscle fiber formation. Myod family inhibitor (Mdfi) inhibits myogenic regulatory factors in NIH3T3 cells, but how Mdfi regulates myoblast myogenic development is still unclear. In the present study, we constructed an Mdfi-overexpression (Mdfi-OE) C2C12 cell line by the CRISPR/Cas9 system and ...
Bo Huang, Yiren Jiao, Yifan Zhu, Zuocheng Ning, Zijian Ye, Qing X. Li, Chingyuan Hu, Chong Wang   +7 more
openaire   +3 more sources

MiR-208b Regulates the Conversion of Skeletal Muscle Fiber Types by Inhibiting Mettl8 Expression

Frontiers in Genetics, 2022
Skeletal muscle, the main source of animal meat products, contains muscle fiber as a key unit. It is well known that transformation takes place between different types of muscle fibers, however, the conversion mechanism is not clear. In a previous study,
Xiang Li, Hanfang Bi, Shanshan Xie, Wentao Cui   +3 more
doaj   +1 more source

Genome-Wide Association Study Identifies CDKN1A as a Novel Locus Associated with Muscle Fiber Composition

Cells, 2022
Muscle fiber composition is associated with physical performance, with endurance athletes having a high proportion of slow-twitch muscle fibers compared to power athletes.
Ekaterina A. Semenova, Hirofumi Zempo, Eri Miyamoto-Mikami, Hiroshi Kumagai, Andrey K. Larin, Rinat I. Sultanov, Konstantin A. Babalyan, Andrey V. Zhelankin, Takuro Tobina, Keisuke Shiose, Ryo Kakigi, Takamasa Tsuzuki, Noriko Ichinoseki-Sekine, Hiroyuki Kobayashi, Hisashi Naito, Jatin Burniston, Edward V. Generozov, Noriyuki Fuku, Ildus I. Ahmetov   +18 more
doaj   +1 more source

Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives

Sports, 2021
Human muscle fibers are generally classified by myosin heavy chain (MHC) isoforms characterized by slow to fast contractile speeds. Type I, or slow-twitch fibers, are seen in high abundance in elite endurance athletes, such as long-distance runners and ...
Daniel L. Plotkin, Michael D. Roberts, Cody T. Haun, Brad J. Schoenfeld   +3 more
doaj   +1 more source

lncRNA-Six1 Is a Target of miR-1611 That Functions as a ceRNA to Regulate Six1 Protein Expression and Fiber Type Switching in Chicken Myogenesis

Cells, 2018
Emerging studies indicate important roles for non-coding RNAs (ncRNAs) as essential regulators in myogenesis, but relatively less is known about their function.
Manting Ma, Bolin Cai, Liang Jiang, Bahareldin Ali Abdalla, Zhenhui Li, Qinghua Nie, Xiquan Zhang   +6 more
doaj   +1 more source

Prediction of muscle fiber composition using multiple repetition testing

Biology of Sport, 2020
Direct determination of muscle fiber composition is invasive and expensive, with indirect methods also requiring specialist resources and expertise. Performing resistance exercises at 80% 1RM is suggested as a means of indirectly estimating muscle fiber ...
Elliott C.R. Hall, Evgeny A Lysenko, Ekaterina A. Semenova, Oleg V. Borisov, Oleg N. Andryushchenko, Liliya B. Andryushchenko, Tatiana F Vepkhvadze, Egor M. Lednev, Piotr Zmijewski, Daniil V Popov, Edward V. Generozov, Ildus I Ahmetov   +11 more
doaj   +1 more source

Capillaries are Embedded in the Sarcolemma of Murine Slow Twitch Skeletal Muscle Fibers

The FASEB Journal, 2012
The purpose of this study was to evaluate the in vivo , 3D spatial relationship between capillaries (CAP), mitochondria (MITO), and three fiber types within murine Tibialis anterior (TA) muscle.
Brian Glancy, Li-Yueh Hsu, Lam Dao, Matthew Bakalar, Stephanie French, David J Chess, Joni L Taylor, Mathew P Daniels, Shervin Esfahani, Robert S Balaban   +9 more
openaire   +1 more source

Need for speed: Human fast-twitch mitochondria favor power over efficiency

Molecular Metabolism
Objective: Human skeletal muscle consists of a mixture of slow- and fast-twitch fibers with distinct capacities for contraction mechanics, fermentation, and oxidative phosphorylation.
Sebastian Edman, Mikael Flockhart, Filip J. Larsen, William Apró   +3 more
doaj   +1 more source

Comparative analysis of the transcriptomes of EDL, psoas, and soleus muscles from mice

BMC Genomics, 2020
Background Individual skeletal muscles have evolved to perform specific tasks based on their molecular composition. In general, muscle fibers are characterized as either fast-twitch or slow-twitch based on their myosin heavy chain isoform profiles.
Pabodha Hettige, Uzma Tahir, Kiisa C. Nishikawa, Matthew J. Gage   +3 more
doaj   +1 more source

Pre-exercise casein peptide supplementation enhances endurance training-induced mitochondrial enzyme activity in slow twitch muscle, but not fast twitch muscle of high fat diet-fed mice

Journal of Physical Fitness and Sports Medicine, 2015
To establish an efficient method of enhancing mitochondrial biogenesis, we investigated the effect of casein peptide supplementation. The aim of this study was to examine whether oral casein peptide ingestion enhances exercise-induced mitochondrial ...
Yutaka Matsunaga, Yuki Tamura, Yumiko Takahashi, Hiroyuki Masuda, Daisuke Hoshino, Yu Kitaoka, Noriko Saito, Hirohiko Nakamura, Yasuhiro Takeda, Hideo Hatta   +9 more
doaj   +1 more source