Results 31 to 40 of about 7,792,195 (427)

Congenital myasthenic syndrome due to rapsyn deficiency: A case report with a new mutation and compound heterozygosity

Medwave, 2019
Introducción Los síndromes miasténicos congénitos son un grupo heterogéneo de desórdenes genéticos, caracterizados por una transmisión sináptica anormal en la placa neuromuscular.
Ivan O. Espinoza, Carolina Reynoso, Giulliana Chávez, Andrew G Engel   +3 more
doaj   +1 more source

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Escher, G., Gensch, E. M., Horton, S. E., Kroger, S., McMahan, U. J., Ruegg, M. A., Tsim, K. W.   +6 more
core   +2 more sources

Passive viscoelastic response of striated muscles [PDF]

Soft Matter, 2022, 18, 3226-3233, 2019
Muscle cells with sarcomeric structure exhibit highly nontrivial passive mechanical response. The difficulty of its continuum modeling is due to the presence of long-range interactions transmitted by extended protein skeleton. To build a rheological model for muscle 'material' we use a stochastic micromodel and derive a linear response theory for a ...
arxiv   +1 more source

Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide [PDF]

, 2014
Reactive oxygen and nitrogen species have been implicated in the loss of skeletal muscle mass and function that occurs during aging. Nitric oxide (NO) and superoxide are generated by skeletal muscle and where these are generated in proximity their ...
A. McArdle, Ali, Balon, Beckman, Braga, Broome, Chang, Close, Cobley, Cortese-Krott, Dubuisson, Erusalimsky, Grozdanovic, Hirschfield, Kobzik, Kojima, Lau, Leiter, Lexell, M.J. Jackson, McConell, Melov, Morley, Muller, Murrant, Nyberg, Palomero, Palomero, Pattwell, Pearson, Porter, Pulliam, Pye, Radi, Reid, Richmonds, Ropelle, Ryall, Sakellariou, Sakellariou, Samengo, Sasaki, Sastre, Sawada, Shefer, Sohal, Song, T. Pearson, Tidball, Trujillo, Vasilaki, Vasilaki, Vasilaki, Vasilaki, Wang, Young   +55 more
core   +2 more sources

Metabolic reprogramming promotes myogenesis during aging [PDF]

, 2019
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a ...
Belli, R, Bonato, A, Caruso, M, Costelli, P, De Angelis, L, Ferraro, E., Leigheb, M, Mirabilii, S, Molfino, A, Muscaritoli, M, Ricciardi, Mr, Tafuri, A   +11 more
core   +3 more sources

Super-Resolution Imaging Reveals the Nanoscale Distributions of Dystroglycan and Integrin Itga7 in Zebrafish Muscle Fibers

Biomedicines, 2023
Cell signaling is determined partially by the localization and abundance of proteins. Dystroglycan and integrin are both transmembrane receptors that connect the cytoskeleton inside muscle cells to the extracellular matrix outside muscle cells ...
Komala Shivanna, Mary Astumian, Prakash Raut, Vinh-Nhan Ngo, Samuel T. Hess, Clarissa Henry   +5 more
doaj   +1 more source

Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy. [PDF]

, 2015
BackgroundDuchenne muscular dystrophy is a fatal cardiac and skeletal muscle disease resulting from mutations in the dystrophin gene. We have previously demonstrated that a dystrophin-associated protein, sarcospan (SSPN), ameliorated Duchenne muscular ...
Crosbie-Watson, Rachelle H, Jordan, Maria C, Marshall, Jamie L, Nguyen, Reginald T, Parvatiyar, Michelle S, Richardson, Vanitra A, Roos, Kenneth P   +6 more
core   +1 more source

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy

Skeletal Muscle, 2013
BackgroundThe childhood neuromuscular disease spinal muscular atrophy (SMA) is caused by mutations or deletions of the survival motor neuron (SMN1) gene.
Justin G. Boyer, L. Murray, Kyle Scott, Y. De Repentigny, J. Renaud, R. Kothary   +5 more
semanticscholar   +1 more source

Insomnia impairs muscle function via regulating protein degradation and muscle clock [PDF]

arXiv, 2023
Background: Insomnia makes people more physically unable of doing daily duties, which results in a lack of strength, leads to lacking in strength. However, the effects of insomnia on muscle function have not yet been thoroughly investigated. So, the objectives of this study were to clarify how insomnia contributes to the decrease of muscular function ...
arxiv