Results 31 to 40 of about 1,090,346 (304)

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]

, 2015
Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya, Cicardi, Maria Elena, Crippa, Valeria, Cristofani, Riccardo, Galbiati, Mariarita, Giorgetti, Elisa, Lieberman, Andrew P., Meroni, Marco, Messi, Elio, Milioto, Carmelo, Pennuto, Maria, Piccolella, Margherita, Polanco, Maria Josefa, Poletti, Angelo, Rocchi, Anna, Rusmini, Paola   +15 more
core   +2 more sources

Expression profiles of muscle disease-associated genes and their isoforms during differentiation of cultured human skeletal muscle cells

BMC Musculoskeletal Disorders, 2012
Background The formation of contractile myofibrils requires the stepwise onset of expression of muscle specific proteins. It is likely that elucidation of the expression patterns of muscle-specific sarcomeric proteins is important to understand muscle ...
Abdul-Hussein Saba, van der Ven Peter F M, Tajsharghi Homa   +2 more
doaj   +1 more source

Identification of proteins from interstitium of trapezius muscle in women with chronic myalgia using microdialysis in combination with proteomics. [PDF]

PLoS ONE, 2012
BACKGROUND: Microdialysis (MD) of the trapezius muscle has been an attractive technique to investigating small molecules and metabolites in chronic musculoskeletal pain in human. Large biomolecules such as proteins also cross the dialysis membrane of the
Patrik Olausson, Björn Gerdle, Nazdar Ghafouri, Britt Larsson, Bijar Ghafouri   +4 more
doaj   +1 more source

Proteomic Analysis of Chicken Skeletal Muscle during Embryonic Development

Frontiers in Physiology, 2017
Embryonic growth and development of skeletal muscle is a major determinant of muscle mass, and has a significant effect on meat production in chicken. To assess the protein expression profiles during embryonic skeletal muscle development, we performed a ...
Hongjia Ouyang, Hongjia Ouyang, Zhijun Wang, Zhijun Wang, Xiaolan Chen, Xiaolan Chen, Jiao Yu, Jiao Yu, Zhenhui Li, Zhenhui Li, Qinghua Nie, Qinghua Nie   +11 more
doaj   +1 more source

Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]

, 2014
Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M, Conboy, Michael, Mamiya, Hikaru, Schaffer, David, Schlesinger, Christina, Yousef, Hanadie, Zeiderman, Matthew   +6 more
core   +6 more sources

STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. [PDF]

PLoS ONE, 2011
Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, skeletal muscle wasting, weight loss and mortality are all positively associated with increased ...
Andrea Bonetto, Tufan Aydogdu, Noelia Kunzevitzky, Denis C Guttridge, Sawsan Khuri, Leonidas G Koniaris, Teresa A Zimmers   +6 more
doaj   +1 more source

Calsequestrins in skeletal and cardiac muscle from adult Danio rerio [PDF]

, 2015
Calsequestrin (Casq) is a high capacity, low affinity Ca2+-binding protein, critical for Ca2+-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms.
Argenton, Francesco, Furlan, Sandra, Mosole, Simone, Murgia, Marta, Nagaraj, Nagarjuna, Nori, Alessandra, Volpe, Pompeo   +6 more
core   +1 more source

Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

Scientific Reports, 2018
Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear.
Maximilian Kleinert, Benjamin L. Parker, Thomas E. Jensen, Steffen H. Raun, Phung Pham, Xiuqing Han, David E. James, Erik A. Richter, Lykke Sylow   +8 more
doaj   +1 more source

The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis

Skeletal Muscle, 2018
Background Members of the ZFP36 family of RNA-binding proteins regulate gene expression post-transcriptionally by binding to AU-rich elements in the 3’UTR of mRNA and stimulating mRNA degradation.
Hema Bye-A-Jee, Dhamayanthi Pugazhendhi, Samuel Woodhouse, Patrick Brien, Rachel Watson, Martin Turner, Jennifer Pell   +6 more
doaj   +1 more source

Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue [PDF]

Clinical and Translational Science, 2013
AbstractReductions in skeletal muscle function occur during the course of healthy aging as well as with bed rest or diverse diseases such as cancer, muscular dystrophy, and heart failure. However, there are no accepted pharmacologic therapies to improve impaired skeletal muscle function.
Melinda, Sheffield-Moore, John E, Wiktorowicz, Kizhake V, Soman, Christopher P, Danesi, Michael P, Kinsky, Edgar L, Dillon, Kathleen M, Randolph, Shannon L, Casperson, Dennis C, Gore, Astrid M, Horstman, James P, Lynch, Barbara M, Doucet, Joni A, Mettler, Jeffrey W, Ryder, Lori L, Ploutz-Snyder, Jean W, Hsu, Farook, Jahoor, Kristofer, Jennings, Gregory R, White, Susan D, McCammon, William J, Durham   +20 more
openaire   +2 more sources