Results 101 to 110 of about 1,366,391 (310)

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle
Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death.
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
doaj   +1 more source

Electrospun Silk Fibroin–Silk Sericin Scaffolds Induced Macrophage Polarization and Vascularization for Volumetric Muscle Loss Injury

Journal of Functional Biomaterials
Volumetric muscle loss (VML) results in the impediment of skeletal muscle function. Tissue engineering scaffolds have been widely developed and used in skeletal muscle regeneration.
Yuqing Wang, Fangyu Ye, Xinbo Wei, Manman Wang, Zheng Xing, Haifeng Liu   +5 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Characteristics of muscle fibers reconstituted in the regeneration process of masseter muscle in an mdx mouse model of muscular dystrophy

, 2006
Mdx mice, which lack dystrophin, were examined for changes in the properties of muscle fibers in the growth process of the masseter muscle at the morphological, protein and transcriptional levels. The slow-type isoform, MyHC-1, and the fast-type isoforms,
김희진
core   +1 more source

Dynamics and epigenetic control of PcG proteins during skeletal muscle cell differentiation [PDF]

, 2010
During skeletal muscle differentiation, signal dependent switches in cell differentiation programs require global rearrangements in repression and activation of lineage specific genes, hence the importance of unravelling epigenetic mechanisms that ...
Prezioso, Carolina
core   +1 more source

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

Advanced Healthcare Materials, EarlyView.
A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Dominic Karl M. Bolinas, Kitz Paul D. Marco, Kim Claudette J. Fernandez, Archana Mishra, Erin Marie D. San Valentin, Jossana A. Damasco, Gino Martin Canlas, Natalie Fowlkes, Richard R. Bouchard, Steven Y. Huang, Marites P. Melancon   +13 more
wiley   +1 more source

Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy

, 2022
Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired methods for the derivation of skeletal muscle cells and their utility in skeletal muscle tissue ...
Eric N. Olson, Olson, Eric N., Sadman M. Sakib, Shahriyari, Mina, Schmidt, Matthias, Rhonda Bassel‐Duby, Gisa, Verena, Schmidt, Jens, Fischer, André, Tiburcy, Malte, Wolfram‐Hubertus Zimmermann, Mina Shahriyari, Linke, Wolfgang A., Harithaa Anandakumar, Winterhoff, Mandy, Zschüntzsch, Jana, Gabriela Salinas, Islam, Md Rezaul, Rinn, Malte, Salinas-Riester, Gabriela, Bassel-Duby, Rhonda S., Zimmermann, Wolfram-Hubertus, Rika, Anastasia, Wolfgang A. Linke, André Fischer, Orr Shomroni, Andreas Unger, Mandy Winterhoff, Sakib, Sadman M., Jens Schmidt, Anastasia Rika, Verena Gisa, Kaurani, Lalit, Salinas, Gabriela, Zimmermann, Wolfram‐Hubertus, Krüger, Dennis, Unger, Andreas, Jana Zschüntzsch, Anandakumar, Harithaa, Malte Rinn, Bassel‐Duby, Rhonda, Shomroni, Orr, Krüger, Dennis Manfred, Dennis Krüger, Matthias Schmidt, Md Rezaul Islam, Lalit Kaurani, Malte Tiburcy   +47 more
core   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

The molecular dysregulation of excitation contraction coupling in patients with congenital muscle disorders [PDF]

, 2015
Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughout the muscle membrane activates muscle contraction, by releasing Ca2+ from the Sarcoplasmic Reticulum (SR).
Rokach, Ori
core   +1 more source

MicroRNAs in the regeneration of skeletal muscle 

Frontiers in Bioscience, 2013
MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes by modulating gene expression at the post-transcriptional level. The discovery of miRNAs as new and important regulators of gene expression is expected to broaden our biological understanding of the regulatory mechanism in muscle by adding another dimension of ...
Xinkai, Yu, Qun, Zuo
openaire   +2 more sources