Results 241 to 250 of about 481,133 (304)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Hydrogel biomaterials that stiffen and soften on demand reveal that skeletal muscle stem cells harbor a mechanical memory. [PDF]

Proc Natl Acad Sci U S A
Madl CM, Wang YX, Holbrook CA, Su S, Shi X, Byfield FJ, Wicki G, Flaig IA, Blau HM.   +8 more
europepmc   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus. [PDF]

Stem Cells
Ismaeel A, Goh J, Mobley CB, Murach KA, Brett JO, de Morrée A, Rando TA, Peterson CA, Wen Y, McCarthy JJ.   +9 more
europepmc   +1 more source

Effect of Chicken Age on Proliferation and Differentiation Abilities of Muscle Stem Cells and Nutritional Characteristics of Cultured Meat Tissue. [PDF]

Food Sci Anim Resour
Kim CJ, Kim SH, Lee EY, Hwang YH, Lee SY, Joo ST.   +5 more
europepmc   +1 more source

Fundamental study on structural formation, amino acids and nucleotide-related compounds of cultivated meat from 3D-cultured pig muscle stem cells. [PDF]

Food Sci Biotechnol
Kim M, Jung HY, Jo C.
europepmc   +1 more source

Methods to Isolate Muscle Stem Cells for Cell-Based Cultured Meat Production: A Review. [PDF]

Animals (Basel)
Lee JH, Kim TK, Kang MC, Park M, Choi YS.   +4 more
europepmc   +1 more source

In vivo PSC differentiation as a platform to identify factors for improving the engraftability of cultured muscle stem cells. [PDF]

Front Cell Dev Biol
Xie N, Robinson K, Sundquist T, Chan SSK.   +3 more
europepmc   +1 more source

Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice. [PDF]

J Cachexia Sarcopenia Muscle
Li F, Zhang F, Shi H, Xia H, Wei X, Liu S, Wu T, Li Y, Shu F, Chen M, Li J, Duan R.   +11 more
europepmc   +1 more source

Lin28a forms an RNA-binding complex with Igf2bp3 to regulate m⁶A-modified stress response genes in stress granules of muscle stem cells. [PDF]

Cell Prolif
Song D, Chen Y, Wang P, Cheng Y, Shyh-Chang N.   +4 more
europepmc   +1 more source