Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Cell ReportsSummary: Cancer cachexia is a debilitating metabolic disorder characterized by involuntary loss of body and muscle mass, leading to increased morbidity and mortality. We previously found that forkhead box P1 (FoxP1) upregulation in skeletal muscle causes
Jeremy B. Ducharme +8 more
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Journal of Cachexia, Sarcopenia and Muscle, 2019 Significant muscle wasting is generally experienced by ill and bed rest patients and older people. Muscle wasting leads to significant decrements in muscle strength, cardiorespiratory, and functional capacity, which increase mortality rates.
Miguel S. Conceição +1 more
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C26 cancer-induced muscle wasting is IKKβ-dependent and NF-kappaB-independent. [PDF]
PLoS ONE, 2014 Existing data suggest that NF-kappaB signaling is a key regulator of cancer-induced skeletal muscle wasting. However, identification of the components of this signaling pathway and of the NF-κB transcription factors that regulate wasting is far from ...
Evangeline W Cornwell +4 more
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The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer [PDF]
, 2018 Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis.
Fairman, C M +5 more
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Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats [PDF]
PeerJ, 2017 Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options are still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be attenuated in response to treatment ...
Anna Salazar-Degracia +4 more
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Exploring metabolic dysfunction in chronic kidney disease [PDF]
, 2012 Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk ...
Slee, Adrian D.
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Ultrasound guided evaluation of muscle wasting in critically ill patients
Egyptian Journal of Critical Care MedicineBackground Muscle wasting constitutes a frequent complication in critical illness and may be most prevalent in chronic critical illness as inpatients with prolonged ICU length of stay.
Alsayed Gaber Ali +3 more
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, 2017 Background; Muscle ring finger 1 (MuRF1) is a muscle‐specific ubiquitin E3 ligase activated during clinical conditions associated with skeletal muscle wasting. Yet, there remains a paucity of therapeutic interventions that directly inhibit MuRF1 function,
Adams +39 more
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A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]
, 2015 Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W. +2 more
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The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]
, 2019 Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio +8 more
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