Results 81 to 90 of about 115,632 (206)

Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy

Frontiers in Oncology
BackgroundEven though doxorubicin (DOX) chemotherapy promotes intense muscle wasting, this drug is still widely used in clinical practice due to its remarkable efficiency in managing cancer.
Edson Alves de Lima Junior, Alexandre Abilio de Souza Teixeira, Loreana Sanches Silveira, Queralt Jové, Natalia Álvarez Ladrón, Marcelo G. Pereira, Francisco Javier López-Soriano, Josep M. Argilés, Patrícia Chakur Brum, Silvia Busquets, José Cesar Rosa Neto   +10 more
doaj   +1 more source

Oxidative stress and muscle homeostasis [PDF]

, 2010
Purpose of review The term oxidative stress is often used to indicate a condition in which the accumulation of reactive oxygen species is considered just damaging.
Fanò, Giorgio, Fulle, Stefania, Musarò, Antonio   +2 more
core   +1 more source

Increased fat accumulation may be associated with severe muscle wasting in critically ill patients: a prospective observational study

Scientific Reports
Obesity has been hypothesized to attenuate muscle wasting in critically ill patients due to increased ketogenesis. This study examined the associations between fat mass volume, ketone bodies, and muscle wasting in critically ill patients.
Yasutaka Koga, Motoki Fujita, Kayoko Harada, Masaru Shin, Ryo Ayata, Tomoaki Inoue, Kotaro Kaneda, Ryosuke Tsuruta   +7 more
doaj   +1 more source

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) [PDF]

, 2012
BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available.
Lin, Shuo, Meinen, Sarina, Ruegg, Markus A.   +2 more
core   +1 more source

Losartan Treatment Attenuates Tumor-induced Myocardial Dysfunction [PDF]

, 2015
Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which ...
Bicer, Sabahattin, Clark, Yvonne, Devine, Raymond D., Jing, Runfeng, McCarthy, Donna O., Reiser, Peter J., Stevens, Sarah C.W., Velten, Markus, Wold, Loren E., Youtz, Dane J.   +9 more
core   +2 more sources

Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway

EBioMedicine, 2017
While angiotensin II (ang II) has been implicated in the pathogenesis of cardiac cachexia (CC), the molecules that mediate ang II's wasting effect have not been identified.
Congcong Shen, Jin Zhou, Xiaoxiao Wang, Xi-Yong Yu, Chun Liang, Bin Liu, Xiangbin Pan, Qiong Zhao, Jenny Lee Song, Jiajun Wang, Meiyu Bao, Chaofan Wu, Yangxin Li, Yao-Hua Song   +13 more
doaj   +1 more source

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy [PDF]

, 2015
OBJECTIVE To expand the clinical phenotype of autosomal dominant congenital spinal muscular atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) gene.
Al-Lozi, Muhammad T, Baas, Frank, Baloh, Robert H, Benatar, Michael, Calissano, Mattia, Chong, W K Kling, Cirak, Sebahattin, Connolly, Anne M, de Goede, Christian G E L, De Visser, Marianne, Fallon, Penny, Foley, A Reghan, Hadjikoumi, Irene, Hafezparast, Majid, Harms, Matthew B, Klein, Andrea, Mansour, Sahar, Manzur, Adnan Y, Martínez Arroyo, Amaia, Mcwilliam, Catherine, Mercuri, Eugenio, Muntoni, Francesco, Nixon, John, Overweg-Plandsoen, W C G Truus, Phadke, Rahul, Pitt, Matthew, Reilly, Mary M, Robb, Stephanie, Rodriguez Sanz, Aida, Rossor, Alexander M, Scoto, Mariacristina, Sewry, Caroline, Taylor, J Paul, Yang, Michele   +33 more
core   +1 more source

The extent of Skeletal muscle wasting in prolonged critical illness and its association with survival: insights from a retrospective single-center study

BMC Anesthesiology
Objective Muscle wasting in critically ill patients, particularly those with prolonged hospitalization, poses a significant challenge to recovery and long-term outcomes.
Johannes Kolck, Clarissa Hosse, Uli Fehrenbach, Nick-Lasse Beetz, Timo Alexander Auer, Christian Pille, Dominik Geisel   +6 more
doaj   +1 more source

Increased circulating levels of interleukin-6 induce perturbation in redox-regulated signaling cascades in muscle of dystrophic mice [PDF]

, 2017
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein.
Forcina, Laura, Musaro', Antonio, Nicoletti, Carmine, Pelosi, Laura, Scicchitano, Bianca Maria   +4 more
core   +3 more sources

Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

EMBO Molecular Medicine
Skeletal muscle wasting results from numerous conditions, such as sarcopenia, glucocorticoid therapy or intensive care. It prevents independent living in the elderly, predisposes to secondary diseases, and ultimately reduces lifespan.
Sang-Hoon Lee, Hyun-Jun Kim, Seon-Wook Kim, Hyunju Lee, Da-Woon Jung, Darren Reece Williams   +5 more
doaj   +1 more source