Results 91 to 100 of about 1,895,992 (345)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effects of a Combined Plyometric and Resistance Training Programme on Adolescent Rugby Union Players

Muscles
Background: Previous work has found that combining plyometric and resistance training in a single session can be effective in improving maximum strength (muscle contraction ability), vertical jumping, and sprint acceleration performance in young soccer ...
Cian M. Walsh, Joseph I. Esformes, Jeremy A. Moody, Paul J. Byrne   +3 more
doaj   +1 more source

Spontaneous physical activity down-regulates Pax7 in cancer cachexia [PDF]

, 2015
Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB - induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that ...
Adamo, Sergio, Annibali, Daniela, Aulino, Paola, Barteri, Fabio, Berardi, Emanuele, Coletti, Dario, Moresi, Viviana, Pigna, Eva   +7 more
core   +5 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effectiveness of Hyperbaric Oxygen Therapy for Musculoskeletal Pain Syndromes: A Systematic Review

Muscles
Background: Musculoskeletal pain syndromes (MPSs) represent a major cause of disability and reduced quality of life, and conventional therapeutic approaches often provide only partial or temporary relief. Hyperbaric oxygen therapy (HBOT) delivered as 100%
Sebastián Eustaquio Martín Pérez, Eduardo Iboleón Laynez, José Antonio Acevedo Rodríguez, María Isabel Maggioni Torres, Roberto Pérez Betancort, Antón Díaz Rodríguez, Diego Cabezos Alonso, Carlos García Camacho, Isidro Miguel Martín Pérez   +8 more
doaj   +1 more source

Electrode for biological recording [PDF]

, 1969
Electrochemically reversible silver-silver chloride electrode for detecting bioelectric potential differences generated by human muscles and ...
Day, J. L., Lippitt, M. W., Jr.
core   +1 more source

The magnitude of the effect of calf muscles fatigue on postural control during bipedal quiet standing with vision depends on the eye-visual target distance [PDF]

, 2005
The purpose of the present experiment was to investigate whether, with vision, the magnitude of the effect of calf muscles fatigue on postural control during bipedal quiet standing depends on the eye-visual target distance.
Amblard, Anand, Bles, Brice Isableu, Bronstein, Corbeil, Cyril Burdet, Edward, Forestier, Guerraz, Horak, Ledin, Ledin, Lord, Massion, Nashner, Nicolas Vuillerme, Nougier, Paulus, Paulus, Redfern, Schmidt, Straube, Sylvain Demetz, Vuillerme, Vuillerme, Vuillerme   +26 more
core   +6 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparing the Force–Time Characteristics Between Countermovement and Assisted Countermovement Jump with Different Landing Strategies

Muscles
Researchers comparing countermovement (CMJ) and assisted countermovement (ACMJ) jumps reported conflicting findings on the landing impact force (LIF). This was likely due to differences in the landing strategies used.
Regine Y. S. Zhou, Lachlan P. James, Danny Lum   +2 more
doaj   +1 more source

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]

, 2018
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi, Escudero Cuadrado, Luis María, Fernández Simón, Esther, Gallardo, Eduard, Gómez Gálvez, Pedro, Piñol Jurado, Patricia, Suárez Calvet, Xavier   +6 more
core   +1 more source