Results 81 to 90 of about 1,895,992 (345)

Rehabilitation interventions for foot drop in neuromuscular disease [PDF]

open access: yes, 2007
"Foot drop" or "Floppy foot drop" is the term commonly used to describe weakness or contracture of the muscles around the ankle joint.
Disler, Peter B.   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Resting Systemic Irisin Concentrations Are Lower in Older versus Younger Males after 12 Weeks of Resistance-Exercise Training While Apelin and IL-15 Concentrations Were Increased in the Whole Cohort

open access: yesMuscles
Myokines released by exercise are identified as factors that can influence a person’s health and wellbeing. While myokine secretion in response to an acute bout of endurance and resistance-type exercise has been examined, the influence of resistance ...
Dean M. Cordingley   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Alternative Treatments to Exercise for the Attenuation of Disuse-Induced Skeletal Muscle Atrophy in Rats

open access: yesMuscles
The prevalence of skeletal muscle atrophy, caused by disease and aging, is rising as life expectancy increases. Exercise is the most effective treatment option; however, it is often impractical for individuals suffering from disease or bedridden.
Jinho Park   +4 more
doaj   +1 more source

Periodic and Chaotic Flapping of Insectile Wings

open access: yes, 2015
Insects use flight muscles attached at the base of the wings to produce impressive wing flapping frequencies. The maximum power output of these flight muscles is insufficient to maintain such wing oscillations unless there is good elastic storage of ...
Huang, Yangyang, Kanso, Eva
core   +1 more source

Spatiotemporal symmetries in the disynaptic canal-neck projection [PDF]

open access: yes, 2007
The vestibular system in almost all vertebrates, and in particular in humans, controls balance by employing a set of six semicircular canals, three in each inner ear, to detect angular accelerations of the head in three mutually orthogonal coordinate ...
Ian Stewart   +4 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

The Effects of Blood Flow Restriction Exercise on Muscle–Brain Crosstalk: A Systematic Review

open access: yesMuscles
Blood flow restriction exercise (BFRE), which partially restricts arterial inflow and occludes venous outflow to the limbs, has gained attention for its potential to elevate serum brain-derived neurotrophic factor (BDNF), a key mediator in the muscle ...
Josh B. Landers   +2 more
doaj   +1 more source

Laryngeal Nerve Activity During Pulse Emission in the CF-FM Bat, Rhinolophus ferrumequinum. II. The Recurrent Laryngeal Nerve [PDF]

open access: yes, 1981
The activity of the recurrent laryngeal nerve (RLN) was recorded in the greater horseshoe bat,Rhinolophus ferrumequinum. Respiration, vocalization and nerve discharges were monitored while vocalizations were elicted by stimulation of the central gray ...
Rübsamen, R., Schuller, Gerd
core   +1 more source

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