Results 121 to 130 of about 28,635 (297)

Identification of gene functions by applying TILLING and insertional mutagenesis strategies on microarray-based expression data

, 2005
Thompson R, Ratet P, Küster H. Identification of gene functions by applying TILLING and insertional mutagenesis strategies on microarray-based expression data. Grain legumes.
Ratet, Pascal, Küster, Helge, Thompson, Richard   +2 more
core  

The Committee for Advanced Therapies' of the European Medicines Agency Reflection Paper on Management of Clinical Risks Deriving from Insertional Mutagenesis

, 2013
n the European Union, the Committee for Advanced Therapies of the European Medicines Agency takes the lead in the scientific assessment for marketing authorization applications for advanced therapy medicinal products, which include gene therapy medicinal
Schneider Christian K, Narayanan Gopalan, Renner Matthias, Galli Maria Cristina, AIUTI , ALESSANDRO, Cossu Giulio, Stahlbom Axel, de Felipe Pablo, Voltz Girolt Caroline   +8 more
core   +2 more sources

HapAsmbl: A reference‐aided pipeline for assembling haplotypes in Nanopore amplicon sequence data of polymorphic populations

Applications in Plant Sciences, EarlyView.
Abstract Premise Advances in long‐read sequencing offer new possibilities to investigate haplotype diversity across multiple genes in plants and other taxa through multi‐locus, long‐read amplicon sequencing (multi‐locus LRAS). Despite this progress, there is a notable absence of dedicated bioinformatics pipelines for assembling diploid haplotypes of ...
Ayodele Oluwaseyi Fakoya, Augustine Chen, Rowan Paul Herridge, Richard Colin Macknight, Lynette Ruth Brownfield   +4 more
wiley   +1 more source

Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation

, 2007
The t(2;11)(q31;p15) chromosomal translocation results in a fusion between the NUP98 and HOXD13 genes and has been observed in patients with myelodysplastic syndrome (MDS) or acute myelogenous leukemia.
Hartung, Helge, Aplan, Peter D., Bies, Juraj, C. Slape, H. Hartung, Y.-W. Lin, L. Wolff, Wolff, Linda, P. D. Aplan, Slape, Christopher, Lin, Ying-Wei, J. Bies   +11 more
core   +1 more source

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Analysis of HIV-2 Vpx by Modeling and Insertional Mutagenesis

, 2006
Vpx facilitates HIV-2 nuclear localization by a poorly understood mechanism. We have compared Vpx to an NMR structure HIV- 1 Vpr in a central helical domain and probed regions of Vpx by insertional mutagenesis.
Ratner, Lee, Mahnke, Lisa A., Belshan, Michael   +2 more
core   +1 more source

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis

Chemistry – A European Journal, EarlyView.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +1 more source

Insertional mutagenesis in Arabidopsis : a tool for functional genomic analysis

, 2000
The completion of the entire Arabidopsis genome sequence has been recently achieved. Approximately 30% of the predicted genes encode for proteins of unknown function, and only 9% of the genes have been characterized experimentally.
M. Galbiati, C. Tonelli
core  

Covalent Insertion of a Mn(Salen) Type Complex in Cross‐Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase

Chemistry – A European Journal, EarlyView.
An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat, Ismail Benhamed, Jade Arnone, Stann Van Baaren, Clara Rinaldi, Patrice Catty, Caroline Marchi‐Delapierre, Christine Cavazza, Stéphane Ménage   +8 more
wiley   +1 more source