Results 11 to 20 of about 664,651 (329)

Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells

BMC Pharmacology and Toxicology, 2022
Background Among the food additives used in the food industry, food dyes are considered the most toxic. For instance, tartrazine (TRZ) is a food colorant commercially available with conflicting data regarding its cytotoxic, genotoxic, and mutagenic ...
Jailson Rodrigues dos Santos, Larissa de Sousa Soares, Bruno Moreira Soares, Marlene de Gomes Farias, Victor Alves de Oliveira, Natan Antônio Batista de Sousa, Helber Alves Negreiros, Felipe Cavalcanti Carneiro da Silva, Ana Paula Peron, Ana Carolina Landim Pacheco, Márcia Maria Mendes Marques, Juan Carlos Ramos Gonçalves, Raquel Carvalho Montenegro, Muhammad Torequl Islam, Javad Sharifi-Rad, Mohammad S. Mubarak, Ana Amélia Carvalho de Melo Cavalcante, João Marcelo de Castro e Sousa   +17 more
doaj   +1 more source

MicroRNAs as a Suitable Biomarker to Detect the Effects of Long-Term Exposures to Nanomaterials. Studies on TiO₂NP and MWCNT

Nanomaterials, 2021
The presence of nanomaterials (NMs) in the environment may represent a serious risk to human health, especially in a scenario of chronic exposure. To evaluate the potential relationship between NM-induced epigenetic alterations and carcinogenesis, the ...
Sandra Ballesteros, Gerard Vales, Antonia Velázquez, Susana Pastor, Mohamed Alaraby, Ricard Marcos, Alba Hernández   +6 more
doaj   +1 more source

Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades

BMC Molecular and Cell Biology, 2020
Background Ubiquitination and ubiquitin-like protein post-translational modifications play an enormous number of roles in cellular processes. These modifications are constituted of multistep reaction cascades.
Gabriel Fenteany, Paras Gaur, Gaurav Sharma, Lajos Pintér, Ernő Kiss, Lajos Haracska   +5 more
doaj   +1 more source

Migration Groups: A Poorly Explored Point of View for Genetic Damage Assessment Using Comet Assay in Human Lymphocytes

Applied Sciences, 2021
A new point of view for genetic damage assessment using the comet assay is proposed based on the number of migration groups, the number of comets in each group, and the groups with the highest number of comets. Human lymphocytes were exposed to different
Mónica Reynoso-Silva, Carlos Álvarez-Moya, Rafael Ramírez-Velasco, Alexis Gerardo Sámano-León, Erandi Arvizu-Hernández, Hugo Castañeda-Vásquez, Mario Alberto Ruíz-Lopez   +6 more
doaj   +1 more source

Screening for Ames mutagenicity of food flavor chemicals by (quantitative) structure-activity relationship

Genes and Environment, 2020
Background (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies.
Masamitsu Honma, Airi Kitazawa, Toshio Kasamatsu, Kei-ichi Sugiyama   +3 more
doaj   +1 more source

High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor [PDF]

, 2014
The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation.
Anke Bill, Anthony Marelli, Anthony P. Orth, BF Binkowski, CY Xiao, D Shortle, D Wang, DA Drummond, DC Koboldt, E Arehart, Elizabeth M. Rosethorne, F Fan, H Wickham, J Cline, J Stitham, J Stitham, J Stitham, J Stitham, J Stitham, J Stitham, J Stitham, J Stitham, J Stitham, JT Kadonaga, K Kuwano, KA Eckert, KA Eckert, KA Martin, KM Egan, KR Tindall, L. Alex Gaither, Lindsay Fawcett, Loren Miraglia, Lynn Burchell, Martin Gosling, Michiel T. van Diepen, NE Labrou, Nicole A. Renaud, O Selifonova, Paul J. Groot-Kormelink, R Stolarski, RA Beckman, RC Cadwell, S Narumiya, S Saito, Sadashiva Karnik, Sergey Batalov, Steven J. Charlton, T Murata, T Vanhercke, TK Sato, Toby C. Kent, TS Rasila, TS Wong, TS Wong, V Giguere, Y Cheng, Z Zhang   +57 more
core   +8 more sources

Pilot study of large-scale production of mutant pigs by ENU mutagenesis

eLife, 2017
N-ethyl-N-nitrosourea (ENU) mutagenesis is a powerful tool to generate mutants on a large scale efficiently, and to discover genes with novel functions at the whole-genome level in Caenorhabditis elegans, flies, zebrafish and mice, but it has never been ...
Tang Hai, Chunwei Cao, Haitao Shang, Weiwei Guo, Yanshuang Mu, Shulin Yang, Ying Zhang, Qiantao Zheng, Tao Zhang, Xianlong Wang, Yu Liu, Qingran Kong, Kui Li, Dayu Wang, Meng Qi, Qianlong Hong, Rui Zhang, Xiupeng Wang, Qitao Jia, Xiao Wang, Guosong Qin, Yongshun Li, Ailing Luo, Weiwu Jin, Jing Yao, Jiaojiao Huang, Hongyong Zhang, Menghua Li, Xiangmo Xie, Xuejuan Zheng, Kenan Guo, Qinghua Wang, Shibin Zhang, Liang Li, Fei Xie, Yu Zhang, Xiaogang Weng, Zhi Yin, Kui Hu, Yimei Cong, Peng Zheng, Hailong Zou, Leilei Xin, Jihan Xia, Jinxue Ruan, Hegang Li, Weiming Zhao, Jing Yuan, Zizhan Liu, Weiwang Gu, Ming Li, Yong Wang, Hongmei Wang, Shiming Yang, Zhonghua Liu, Hong Wei, Jianguo Zhao, Qi Zhou, Anming Meng   +58 more
doaj   +1 more source

Polystyrene Nanoplastics as Carriers of Metals. Interactions of Polystyrene Nanoparticles with Silver Nanoparticles and Silver Nitrate, and Their Effects on Human Intestinal Caco-2 Cells

Biomolecules, 2021
Environmental plastic wastes are continuously degraded to their micro and nanoforms. Since in the environment they coexist with other pollutants, it has been suggested that they could act as vectors transporting different toxic trace elements, such as ...
Josefa Domenech, Constanza Cortés, Lourdes Vela, Ricard Marcos, Alba Hernández   +4 more
doaj   +1 more source

Purification and interactions of the MucA’ and MucB proteins constituting the DNA polymerase RI

Genes and Environment, 2019
Background The MucA’ and MucB proteins comprise the core of DNA polymerase RI which is a strong mutator utilized in mutagenicity assays such as the standard Ames test. A close relative DNA polymerase V, composed of the homologous UmuD’ and UmuC proteins,
Petr Grúz, Kei-ichi Sugiyama, Masamitsu Honma, Takehiko Nohmi   +3 more
doaj   +1 more source

Targeted mutagenesis of the Sap47 gene of Drosophila: Flies lacking the synapse associated protein of 47 kDa are viable and fertile [PDF]

, 2004
BACKGROUND: Conserved proteins preferentially expressed in synaptic terminals of the nervous system are likely to play a significant role in brain function.
Becker, Sonja, Brunner, Marion, Buchner, Erich, Funk, Natalja, Huber, Saskia   +4 more
core   +3 more sources