Results 31 to 40 of about 465,278 (302)

Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research [PDF]

, 2016
Mitochondrial diseases have been extensively investigated over the last three decades but many questions regarding their underlying aetiologies remain unanswered.
Paraskevaidi, Maria, Kyrgiou, Maria, Martin, Francis L, Paraskevaidi, M, Martin-Hirsch, PL, Martin, FL, Martin-Hirsch, Pierre L., Kyrgiou, M   +7 more
core   +1 more source

Rapid construction of mycobacterial mutagenesis vectors using ligation-independent cloning [PDF]

, 2010
Targeted mutagenesis is one of the major tools for determining the function of a given gene and its involvement in bacterial pathogenesis. In mycobacteria, gene deletion is often accomplished by using allelic exchange techniques that commonly utilise a ...
Neil G. Stoker, Stoker, N G, Francois-Xavier Chauviac, Balhana, R J C, Sikder, M H, Stoker, Neil G., Chauviac, Francois-Xavier, Sharon L. Kendall, Sikder, Mahmudul Hasan, Kendall, S L, Birkbeck College, Chauviac, F-X, Mahmudul Hasan Sikder, Kendall, Sharon L., Ricardo Balhana, Balhana, Ricardo   +15 more
core   +1 more source

Evaluation of oxidative stress responses in human circulating blood cells after imatinib mesylate treatment – Implications to its mechanism of action

Saudi Pharmaceutical Journal, 2019
Imatinib mesylate (IM) is the first developed protein kinase inhibitor and recently it has topped consumption rates among targeted and total anticancer drugs.
Goran Gajski, Marko Gerić, Ana-Marija Domijan, Ivana Golubović, Vera Garaj-Vrhovac   +4 more
doaj   +1 more source

Genome-Wide and Exome-Capturing Sequencing of a Gamma-Ray-Induced Mutant Reveals Biased Variations in Common Wheat

Frontiers in Plant Science, 2022
Induced mutagenesis is a powerful approach for the creation of novel germplasm and the improvement of agronomic traits. The evaluation of mutagenic effects and functional variations in crops is needed for breeding mutant strains.
Yuting Li, Yuting Li, Hongchun Xiong, Jiazi Zhang, Huijun Guo, Chunyun Zhou, Yongdun Xie, Linshu Zhao, Jiayu Gu, Shirong Zhao, Yuping Ding, Zhengwu Fang, Luxiang Liu   +12 more
doaj   +1 more source

Large-scale identification of pathogenicity factors in "Bartonella" by signature-tagged mutagenesis [PDF]

, 2005
Bartonellae are bacterial pathogens uniquely adapted to cause intraerythrocytic infection in their mammalian reservoir hosts. In the case of human-specific Bartonella bacilliformis and Bartonella quintana, the intraerythrocytic bacteremia leads to the ...
Saenz Dürrmeier, Luis-Henri
core   +1 more source

Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA

Genes and Environment, 2019
Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repair (RER), inactivation of RER causes genomic ...
Akira Sassa, Manabu Yasui, Masamitsu Honma   +2 more
doaj   +1 more source

Identification of the vernalization gene VRN-B1 responsible for heading date variation by QTL mapping using a RIL population in wheat

BMC Plant Biology, 2020
Background Heading time is one of the most important agronomic traits in wheat, as it largely affects both adaptation to different agro-ecological conditions and yield potential.
Yuting Li, Hongchun Xiong, Huijun Guo, Chunyun Zhou, Yongdun Xie, Linshu Zhao, Jiayu Gu, Shirong Zhao, Yuping Ding, Luxiang Liu   +9 more
doaj   +1 more source

Development of a simple multiple mutation detection system using seed-coat flavonoid pigments in irradiated Arabidopsis M1 plants

Scientific Reports, 2022
Ionizing radiation induces genetic variations in plants, which makes it useful for plant breeding. A theory that the induced mutations occur randomly in the genome has long been accepted, but is now controversial.
Satoshi Kitamura, Shoya Hirata, Katsuya Satoh, Rie Inamura, Issay Narumi, Yutaka Oono   +5 more
doaj   +1 more source

Transposon mutagenesis in Mycoplasma hyopneumoniae using a novel mariner-based system for generating random mutations. [PDF]

, 2013
Mycoplasma hyopneumoniae is the cause of enzootic pneumonia in pigs, a chronic respiratory disease associated with significant economic losses to swine producers worldwide.
Maskell, Duncan J, Tucker, AW, Andrew N Rycroft, Rycroft, Andrew N, Rycroft, AN, Beth S Cook, Deeney, A S, Tucker, A W, Maglennon, Gareth A, Cook, BS, Wren, Brendan W, Bossé, J T, Janine T Bossé, Duncan J Maskell, LSHTM, Peters, SE, Bossé, Janine T, Peters, Sarah E, Tucker, Alexander W, Peters, S E, Langford, PR, Cook, Beth S, BRaDP1T consortium, Rycroft, A N, Sarah E Peters, Bossé, JT, Deeney, Alannah S, Wren, BW, Cook, B S, Maglennon, GA, Maskell, D J, Wren, B W, Alannah S Deeney, Alexander W Tucker, Paul R Langford, Langford, P R, Maskell, DJ, Gareth A Maglennon, Langford, Paul R, null null, Deeney, AS, Maglennon, G A, Brendan W Wren   +42 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source