Results 51 to 60 of about 465,278 (302)
Frontiers in ToxicologyBackgroundThe presence of micro- and nanoplastics (MNPLs) in human blood raises concerns about their vascular impact and their potential contribution to cardiovascular diseases.
Joan Martín-Pérez +10 more
doaj +1 more source
Journal of Integrative Agriculture, 2020 Low stature in wheat is closely associated with lodging resistance, and this impacts harvest index and grain yield. The discovery of novel dwarfing or semi-dwarfing genes can have great significance for dwarf wheat breeding.
Chun-yun ZHOU +10 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage
Radiation Oncology, 2019 Doxycycline (DXC) is a tetracycline antibiotic which has been proposed as a breast cancer radiosensitizer by specifically reducing the expression of the DNA repair enzyme DNA PK in breast cancer initiating cells.
Guido Frosina +3 more
doaj +1 more source
Frontiers in Genetics, 2021 Blast is caused by the host-specific lineages of the fungus Magnaporthe oryzae and is the most important destructive disease in major crop plants, including rice and wheat. The first wheat blast outbreak that occurred in Bangladesh in 2016 and the recent
Huijun Guo +9 more
doaj +1 more source
, 2018 Saturation mutagenesis of all endogenous genes within the mouse genome remains a challenging task, although a plenty of gene-editing approaches are available for this purpose.
Shan Zhong +11 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
p53 Mutations and DNA Ploidy in Colorectal Adenocarcinomas
Analytical Cellular Pathology, 1998 The p53 tumour suppressor gene has an important role in the the maintenance of genome stability and its mutational inactivation may be at the origin of aneuploidy in cancer cells.
Paola Campomenosi +12 more
doaj +1 more source
BMC Plant Biology, 2023 Background Induction of mutation through chemical mutagenesis is a novel approach for preparing diverse germplasm. Introduction of functional alleles in the starch biosynthetic genes help in the improvement of the quality and yield of cereals. Results In
Ahsan Irshad +10 more
doaj +1 more source
Optimization of Combinatorial Mutagenesis [PDF]
Journal of Computational Biology, 2011 Abstract Protein engineering by combinatorial site-directed mutagenesis evaluates a portion of the sequence space near a target protein, seeking variants with improved properties (e.g., stability, activity, immunogenicity).
Andrew S. Parker +2 more
openaire +3 more sources