Results 51 to 60 of about 627,903 (299)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Transcriptomic and functional profiling of endothelial dysfunction induced by polystyrene nanoplastics

Frontiers in Toxicology
BackgroundThe presence of micro- and nanoplastics (MNPLs) in human blood raises concerns about their vascular impact and their potential contribution to cardiovascular diseases.
Joan Martín-Pérez, Aliro Villacorta, Aliro Villacorta, Javier Gutiérrez-García, Raquel Egea, Michelle Morataya-Reyes, Mireia Cassú-Casadevall, Irene Barguilla, Ricard Marcos, Alba Hernández, Alba García-Rodríguez   +10 more
doaj   +1 more source

Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage

Radiation Oncology, 2019
Doxycycline (DXC) is a tetracycline antibiotic which has been proposed as a breast cancer radiosensitizer by specifically reducing the expression of the DNA repair enzyme DNA PK in breast cancer initiating cells.
Guido Frosina, Daniela Marubbi, Diana Marcello, Antonio Daga   +3 more
doaj   +1 more source

Identification of Rice Blast Loss-of-Function Mutant Alleles in the Wheat Genome as a New Strategy for Wheat Blast Resistance Breeding

Frontiers in Genetics, 2021
Blast is caused by the host-specific lineages of the fungus Magnaporthe oryzae and is the most important destructive disease in major crop plants, including rice and wheat. The first wheat blast outbreak that occurred in Bangladesh in 2016 and the recent
Huijun Guo, Qidi Du, Yongdun Xie, Hongchun Xiong, Linshu Zhao, Jiayu Gu, Shirong Zhao, Xiyun Song, Tofazzal Islam, Luxiang Liu   +9 more
doaj   +1 more source

Glycolytic enzymes - novel carbohydrate binding proteins for glycoprotein analysis [PDF]

, 2011
•The cloning, expression, purification and characterisation of recombinant prokaryotic glycolytic enzymes •The mutagenesis of prokaryotic glycolytic enzymes to generate novel recombinant carbohydrate binding proteins •The characterisation of the ...
Clarke, Paul A., Harrington, Amy, O'Connor, Brendan, Thompson, Roisin   +3 more
core  

Differences in collagen prolyl 4-hydroxylase assembly between two Caenorhabditis nematode species despite high amino acid sequence identity of the enzyme subunits [PDF]

, 2007
The collagen prolyl 4-hydroxylases (P4Hs) are essential for proper extracellular matrix formation in multicellular organisms. The vertebrate enzymes are α2β2 tetramers, in which the β subunits are identical to protein disulfide ...
Abrams, Alan D. Winter, Annunen, Annunen, Annunen, Antony P. Page, Bessereau, Crossen, D'Andrea, Friedman, Gillian McCormack, Helaakoski, Hieta, Hill, Johanna Myllyharju, John, Katriina Keskiaho, Kivirikko, Kivirikko, Kukkola, Lamberg, Liisa Kukkola, Marie-Anne Felix, Merriweather, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Nissi, Page, Pekkala, Quevillon, Riihimaa, Stein, Sulston, Thein, Van den Diepstraten, Veijola, Veijola, Vuori, Williams, Winter, Winter   +44 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Genetic analysis and QTL mapping of a novel reduced height gene in common wheat (Triticum aestivum L.)

Journal of Integrative Agriculture, 2020
Low stature in wheat is closely associated with lodging resistance, and this impacts harvest index and grain yield. The discovery of novel dwarfing or semi-dwarfing genes can have great significance for dwarf wheat breeding.
Chun-yun ZHOU, Hong-chun XIONG, Yu-ting LI, Hui-jun GUO, Yong-dun XIE, Lin-shu ZHAO, Jia-yu GU, Shi-rong ZHAO, Yu-ping DING, Xi-yun SONG, Lu-xiang LIU   +10 more
doaj   +1 more source

Evaluation of altered starch mutants and identification of candidate genes responsible for starch variation in wheat

BMC Plant Biology, 2023
Background Induction of mutation through chemical mutagenesis is a novel approach for preparing diverse germplasm. Introduction of functional alleles in the starch biosynthetic genes help in the improvement of the quality and yield of cereals. Results In
Ahsan Irshad, Huijun Guo, Hongchun Xiong, Yongdun Xie, Hua Jin, Jiayu Gu, Chaojie Wang, Liqun Yu, Xianghui Wen, Shirong Zhao, Luxiang Liu   +10 more
doaj   +1 more source

Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana. [PDF]

, 2014
Low linear energy transfer (LET) gamma rays and high LET HZE (high atomic weight, high energy) particles act as powerful mutagens in both plants and animals.
Britt, Anne B, Conklin, Phillip A, Friesner, Joanna D, Huefner, Neil D, Yoshiyama, Kaoru   +4 more
core   +1 more source