Results 61 to 70 of about 465,278 (302)

Structural Characterization of Agonist Binding to A3 Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments [PDF]

, 2019
The study aimed at highlighting features of the still-unsolved A3R that are important for IB-MECA and NECA binding and may be used for the design of effective ligands using computational and mutagenesis studies.
Antonios, Kolocouris, Panagiotis, Lagarias, Graham, Ladds, Dimitrios, Stamatis, Kerry, Barkan, Eleni, Vrontaki   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Hazard Assessment of Polystyrene Nanoplastics in Primary Human Nasal Epithelial Cells, Focusing on the Autophagic Effects

Biomolecules, 2023
The human health risks posed by micro/nanoplastics (MNPLs), as emerging pollutants of environmental/health concern, need to be urgently addressed as part of a needed hazard assessment.
Balasubramanyam Annangi, Aliro Villacorta, Montserrat López-Mesas, Victor Fuentes-Cebrian, Ricard Marcos, Alba Hernández   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Biological Impact of True-to-Life PET and Titanium-Doped PET Nanoplastics on Human-Derived Monocyte (THP-1) Cells

Nanomaterials
In the environment, plastic waste degrades into small particles known as microplastics and nanoplastics (MNPLs), depending on their size. Given the potential harmful effects associated with MNPL exposure, it is crucial to develop environmentally ...
Aliro Villacorta, Michelle Morataya-Reyes, Lourdes Vela, Jéssica Arribas Arranz, Joan Martín-Perez, Irene Barguilla, Ricard Marcos, Alba Hernández   +7 more
doaj   +1 more source

Functional mutation allele mining of plant architecture and yield-related agronomic traits and characterization of their effects in wheat

BMC Genetics, 2019
Background Wheat mutant resources with phenotypic variation have been developed in recent years. These mutants might carry favorable mutation alleles, which have the potential to be utilized in the breeding process.
Huijun Guo, Hongchun Xiong, Yongdun Xie, Linshu Zhao, Jiayu Gu, Shirong Zhao, Yuping Ding, Luxiang Liu   +7 more
doaj   +1 more source

Comprehensive framework between environment and genomic stability: the open symposium of the Japanese Environmental Mutagen Society (JEMS) in 2019

Genes and Environment, 2019
The open symposium of the Japanese Environmental Mutagen Society (JEMS), under the title of “Comprehensive framework between environment and genomic stability,” was held in the Main Conference Room of the Foundation for Promotion of Cancer Research ...
Katsuyoshi Horibata, Masashi Sekimoto, Kei-ichi Sugiyama   +2 more
doaj   +1 more source

TILLING in Cereal Crops for Allele Expansion and Mutation Detection by Using Modern Sequencing Technologies

Agronomy, 2020
A substantial increase in yield of food crops is crucial to feeding the burgeoning global population. There is a need to introduce new breeding strategies that will accelerate the average phenotypic values of crop plants.
Ahsan Irshad, Huijun Guo, Shunlin Zhang, Luxiang Liu   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Genetic variation in arsenic (+3 oxidation state) methyltransferase (AS3MT), arsenic metabolism and risk of basal cell carcinoma in a European population. [PDF]

, 2014
Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated ...
Koppova, K, Vahter, Marie, Broberg Palmgren, Karin, Kumar, Rajiv, Fletcher, T, Engström, Karin S, Broberg, K,, Goessler, W, Engstrom, KS, Koppova, Kvetoslava, Rudnai, Peter, Gurzau, E, Gurzau, Eugen, Goessler, Walter, Leonardi, Giovanni, Leonardi, G, Rudnai, P, Engström, Karin, Vahter, M,, Broberg, Karin, Fletcher, Tony, Kumar, R, Engström, Karin,, Broberg Palmgren, Karin,, Lund University.   +24 more
core   +1 more source