Results 61 to 70 of about 352,449 (219)

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Mutations in the superoxide-responsive regulator SoxR confer fluoroquinolone resistance in <i>Stenotrophomonas maltophilia</i>. [PDF]

Curr Res Microb Sci
Kanawong P, Tipanyo P, Poomchuchit S, Mongkolsuk S, Vattanaviboon P, Charoenlap N.   +5 more
europepmc   +1 more source

Achieving High‐Density and Stress‐Resilient Maize Breeding Via Germplasm Innovation

Advanced Science, EarlyView.
Global population growth and climate change have exacerbated the global food crisis. This perspective presents a conceptual framework focusing on enhancing population advantages. Several novel breeding objectives are proposed to improve density tolerance and stress resistance for yield improvement.
Xinlong Li, Yongqiang Chen, Dong Ding, Xuehai Zhang, Xuxiang Jia, Zhanhui Zhang, Yafei Wang, Weihua Li, Hui Zhang, Jihua Tang   +9 more
wiley   +1 more source

Transposon-based genome editing of industrial microorganisms: advances, challenges, and prospects. [PDF]

Synth Syst Biotechnol
Zhang Z, Huang Z, Wang Y, Li Z, Wen Z, Gu Y.   +5 more
europepmc   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Ethyl methanesulfonate mutagenesis in fungi: genetic mechanisms, applications, and implications for agricultural biotechnology. [PDF]

Arch Microbiol
Holman DE, Abrahams AI, Hattingh K, Saulse C, Hess M, Stegmann D, Roomanay M, Basson G, Klein A, Keyster M.   +9 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses. [PDF]

G3 (Bethesda)
Kockler ZW, Bostan H, Klimczak LJ, Hsiao YC, Dennen MS, Cook ME, Mertz TM, Perelygina L, Kazanov MD, Li JL, Roberts SA, Gordenin DA.   +11 more
europepmc   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Iterative evolution of <i>Saccharomyces cerevisiae</i> enhances recombinant protease secretion. [PDF]

Synth Syst Biotechnol
Liu X, Lian M, Zeng J, Zheng L, Zhao M, Huang M.   +5 more
europepmc   +1 more source