Results 21 to 30 of about 465,278 (302)

Purification and interactions of the MucA’ and MucB proteins constituting the DNA polymerase RI

Genes and Environment, 2019
Background The MucA’ and MucB proteins comprise the core of DNA polymerase RI which is a strong mutator utilized in mutagenicity assays such as the standard Ames test. A close relative DNA polymerase V, composed of the homologous UmuD’ and UmuC proteins,
Petr Grúz, Kei-ichi Sugiyama, Masamitsu Honma, Takehiko Nohmi   +3 more
doaj   +1 more source

Antigenotoxic Effect of Ascorbic Acid and Resveratrol in Erythrocytes of Ambystoma mexicanum, Oreochromis niloticus and Human Lymphocytes Exposed to Glyphosate

Current Issues in Molecular Biology, 2022
Glyphosate is a controversial herbicide. Its genotoxicity and presence in various ecosystems have been reported. The use of ascorbic acid and resveratrol could protect different organisms from glyphosate-induced genetic damage.
Carlos Alvarez-Moya, Alexis Gerardo Sámano-León, Mónica Reynoso-Silva, Rafael Ramírez-Velasco, Mario Alberto Ruiz-López, Alma Rosa Villalobos-Arámbula   +5 more
doaj   +1 more source

Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. [PDF]

, 2001
peer reviewedBACKGROUND: The ENU Mouse Mutagenesis Project aims at a large-scale, systematic production of mouse mutants using the alkylating agent ethyl-nitrosourea (ENU).
Wolf, A., Behrendt, Heidrun, Alessandrini, Francesca, Behrend, H., Ring, J., Wolf, Alexander, Ring, Johannes, Jakob, T., Hrabe de Angelis, M., Jakob, Thilo, Alessandrini, F., BALLING, Rudi, Wolf, Eckhard, Behrendt, H., Hrabé de Angelis, Martin, Wolf, E., Balling, R., Balling, Rudolf, Alessandrini, F. ; Jakob, T. ; Wolf, A. ; Wolf, E. ; Balling, R. ; Hrabé de Angelis, M. ; Ring, J. ; Behrend, H., Alessandrini, Francesca;Jakob, Thilo;Wolf, Alexander;Wolf, Eckhard;Balling, Rudolf;de Angelis, Martin Hrabe;Ring, Johannes;Behrendt, Heidrun   +19 more
core   +1 more source

Implementation of transposon mutagenesis in Bifidobacterium [PDF]

, 2019
Random transposon mutagenesis allows for relatively rapid, genome-wide surveys to detect genes involved in functional traits, by performing screens of mutant libraries. This approach has been widely applied to identify genes responsible for activities of
van Sinderen, Douwe, Lorena Ruiz, Ruiz, Lorena, Douwe van Sinderen   +3 more
core   +1 more source

Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway [PDF]

, 2006
Mormann S, Lömker A, Rückert C, et al. Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway. BMC Genomics.
Mormann, Sascha, Rückert, Christian ; https://orcid.org/, Tauch, Andreas, Lömker, Alexander, Gaigalat, Lars, Pühler, Alfred ; https://orcid.org/, Kalinowski, Jörn   +6 more
core   +1 more source

UV- and MMS-induced mutagenesis of lambdaO(am)8 phage under nonpermissive conditions for phage DNA replication. [PDF]

, 2003
Mutagenesis in Escherichia coli, a subject of many years of study is considered to be related to DNA replication. DNA lesions nonrepaired by the error-free nucleotide excision repair (NER), base excision repair (BER) and recombination repair (RR), stop ...
Felczak, Magdalena, Krwawicz, Joanna, Pietrzykowska, Irena, Czajkowska, Anna   +3 more
core   +1 more source

Mutagenesis [PDF]

, 2012
The complexity of problem understanding biochemical and molecular basis of healthy life, and eagerness to find simple solution necessitate evolution of technology like mutagenesis.

core   +2 more sources

Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: the special case of molnupiravir

, 2022
This review considers antiviral nucleoside analog drugs, including ribavirin, favipiravir, and molnupiravir, which induce genome error catastrophe in SARS-CoV or SARS-CoV-2 via lethal mutagenesis as a mode of action.
Claude Hughes, Philip Lewis, Hughes, Claude, Warren, Stafford, Michael D. Waters, Fengyu Zhang, Waters, Michael D, Lewis, Philip, Stafford Warren, Zhang, Fengyu   +9 more
core   +1 more source

VH-RELATED IDIOTOPES DETECTED BY SITE-DIRECTED MUTAGENESIS [PDF]

, 1992
The function of the CD4 cell surface protein as coreceptor on T helper lymphocytes and as receptor for HIV makes this glycoprotein a prime target for an immune intervention with mAb.
Rieber, Ernst Peter, Weissenhorn, Winfried, Weiss, Elisabeth H., Cheng, Y. H., Riethmüller, Gert   +4 more
core   +1 more source

Identification of Single Nucleotide Polymorphism in TaSBEIII and Development of KASP Marker Associated With Grain Weight in Wheat

Frontiers in Genetics, 2021
Manipulation of genes involved in starch synthesis could significantly affect wheat grain weight and yield. The starch-branching enzyme (SBE) catalyzes the formation of branch points by cleaving the α-1,4 linkage in polyglucans and reattaching the chain ...
Ahsan Irshad, Huijun Guo, Shoaib Ur Rehman, Xueqing Wang, Jiayu Gu, Hongchun Xiong, Yongdun Xie, Linshu Zhao, Shirong Zhao, Chaojie Wang, Luxiang Liu   +10 more
doaj   +1 more source