Results 21 to 30 of about 627,903 (299)
Saturation mutagenesis reveals manifold determinants of exon definition. [PDF]
, 2017 To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene.
Anquetil, Vincent +9 more
core +2 more sources
Current Issues in Molecular Biology, 2022 Glyphosate is a controversial herbicide. Its genotoxicity and presence in various ecosystems have been reported. The use of ascorbic acid and resveratrol could protect different organisms from glyphosate-induced genetic damage.
Carlos Alvarez-Moya +5 more
doaj +1 more source
In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]
, 2015 The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra +5 more
core +1 more source
Cytogenetic and Genome Research, 1998 Abstract Revising this chapter engendered the thought that perhaps the days of large scale screens for mutations had waned. But the genome projects have described many genes (ORFs), or expressed sequences, for which no known function exists, and this provides impetus for the isolation of mutations in specific genes or regions of the ...
+6 more sources
Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus [PDF]
, 1987 The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator.
Bertholet, Christine +4 more
core +4 more sources
Frontiers in Genetics, 2021 Manipulation of genes involved in starch synthesis could significantly affect wheat grain weight and yield. The starch-branching enzyme (SBE) catalyzes the formation of branch points by cleaving the α-1,4 linkage in polyglucans and reattaching the chain ...
Ahsan Irshad +10 more
doaj +1 more source
Scientific Reports, 2022 Ionizing radiation induces genetic variations in plants, which makes it useful for plant breeding. A theory that the induced mutations occur randomly in the genome has long been accepted, but is now controversial.
Satoshi Kitamura +5 more
doaj +1 more source
Plasmid copy number underlies adaptive mutability in bacteria. [PDF]
, 2014 The origin of mutations under selection has been intensively studied using the Cairns-Foster system, in which cells of an Escherichia coli lac mutant are plated on lactose and give rise to 100 Lac+ revertants over several days. These revertants have been
Aboubechara, John Paul +4 more
core +1 more source
Saudi Pharmaceutical Journal, 2019 Imatinib mesylate (IM) is the first developed protein kinase inhibitor and recently it has topped consumption rates among targeted and total anticancer drugs.
Goran Gajski +4 more
doaj +1 more source
DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]
, 2017 Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao +6 more
core +3 more sources