Results 111 to 120 of about 136,223 (377)

The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds [PDF]

, 2015
Following in utero exposure to low dose radiation (10 – 200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment.
Ahlbom IC, Bayer SA, Brenner DJ, Cox J, Crumpton MJ, Ding GR, Draper G, Elizabeth Ainsbury, Fedele G, Gatz SA, Greenland S, International Agency for Research on Cancer (IARC), Ivancsits S, Jackie Haines, Kabacik S, Lagroye I, Lara Barazzuol, Lisa Woodbine, Luukkonen J, Luukkonen J, Maeda K, Mairs RJ, Margaret Coster, Mettler FA, Mitsuhashi T, O’Dea AR, Penny Jeggo, Pontious A, World Health Organization (WHO), Zenon Sienkiewicz, Zhao L   +30 more
core   +2 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Assessment of the genetic risks of a metallic alloy used in medical implants

Genetics and Molecular Biology, 2011
The use of artificial implants provides a palliative or permanent solution for individuals who have lost some bodily function through disease, an accident or natural wear. This functional loss can be compensated for by the use of medical devices produced
Cristiano C. Gomes, Leonardo M. Moreira, Vanessa J.S.V. Santos, Alfeu S. Ramos, Juliana P. Lyon, Cristina P. Soares, Fabio V. Santos   +6 more
doaj  

Anti-Inflammatory, Cytotoxic, and Genotoxic Effects of Soybean Oligopeptides Conjugated with Mannose

Foods
Soy protein is considered to be a high-quality protein with a range of important biological functions. However, the applications of soy protein are limited due to its poor solubility and high level of allergenicity.
Pornsiri Pitchakarn, Pensiri Buacheen, Sirinya Taya, Jirarat Karinchai, Piya Temviriyanukul, Woorawee Inthachat, Supakit Chaipoot, Pairote Wiriyacharee, Rewat Phongphisutthinant, Sakaewan Ounjaijean, Kongsak Boonyapranai   +10 more
doaj   +1 more source

Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity

Swiss Medical Weekly, 2012
After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and
Damien van Berlo, Martin J D Clift, Catrin Albrecht, Roel P F Schins   +3 more
doaj   +1 more source

DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure [PDF]

, 2018
Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls.
Balali-Mood, Mahdi, Behravan, Effat, Blain, Peter, Jowsey, Paul, Khateri, Shahriar, Sadeghi, Mahmood, Soroush, Mohammad Reza, Williams, Faith   +7 more
core   +2 more sources

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

How to Explain Individual Classification Decisions

, 2009
After building a classifier with modern tools of machine learning we typically have a black box at hand that is able to predict well for unseen data.
Baehrens, David, Hansen, Katja, Harmeling, Stefan, Kawanabe, Motoaki, Mueller, Klaus-Robert, Schroeter, Timon   +5 more
core  

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources