Results 121 to 130 of about 136,223 (377)

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Augmented cytotoxic, mutagenic and genotoxic response triggered by carvedilol and celecoxib combinations [PDF]

, 2018
Ali Attiq, Muhammad Ashraf, Juriyati Jalil, Aqeel Javeed, Aftab Ahmad Anjum, Asad Ullah, Muhammad Umair, Sarwat Ali   +7 more
openalex   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Study of Mutagenicity of Metabolized Pollutants in Some Tissues of Black Gobby (Gobius niger) and Black Mussels(Mytilus galloprovincialis) from Izmir Bay (Western Turkey) [PDF]

, 2011
Meltem Boyacıoğlu, Hatice Parlak, Ozlem Cakal Arsl, elma Katalay, Muhammet Ali Karasl   +4 more
openalex   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Effect of Hom Nil Rice and Black Glutinous Rice Extracts during Treatment of Chicken Extract with Sodium Nitrite Using Ames Test

Journal of Health Science and Medical Research (JHSMR), 2014
The previous study indicated that the extracts of three form of Hom Nil rice (Oryza sativa) and black glutinous rice (Oryza sativa var. glutinosa); raw, cooked and fermented were not mutagenic.
Kamala Sadabpod, Linna Tongyonk, Kaew Kangsadalampai   +2 more
doaj  

A descriptor-based analysis to highlight the mechanistic rationale of mutagenicity

, 2021
Domenico Gadaleta, Emilio Benfenati
openalex   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Phytochemical Content and Antioxidant Activity in Tradisional Balinese Babi-guling Spices [PDF]

, 2011
The traditional Balinese richly spiced swine-grill (Babi-guling) has been increasingly popular even among both the domestic and foreign tourists. The traditional grill is very unique in taste as it contains two main components, i.e.
Indraguna Pinatih, G N, Muliartha, I. (IKG), Santosa, A. (A), Suryadhi, N. (NT)   +3 more
core  

Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer [PDF]

, 2017
Irina G. Minko, Carmelo J. Rizzo, R. Stephen Lloyd   +2 more
openalex   +1 more source