Results 171 to 180 of about 20,243 (238)

Molecular insights into the bioactivity of H-thiazine compounds against breast cancer cells: a computational study. [PDF]

In Silico Pharmacol
Mogoane LM, Obakachi VA, Govender PP, Govender KK.   +3 more
europepmc   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

In vivo and in vitro genotoxicity of N-nitrosopyrrolidine following UVA irradiation. [PDF]

Genes Environ
Hanaki Y, Arimoto-Kobayashi S.
europepmc   +1 more source

Intermittent Fasting Enhances Genome Integrity and Cytoprotective Pathways via (BHB) β‐Hydroxybutyrate Signaling and Chromatin Remodeling

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Repeated intermittent fasting elevates hippocampal β‐hydroxybutyrate (BHB), remodels HDAC activity and histone acetylation, and drives a metabolic–epigenetic transition from transient chromatin priming after a single fast to a sustained cytoprotective program associated with reduced DNA damage and enhanced genome maintenance.
Hadar Parnas, Joanna Bartman, Tali Rosenberg, Ronit Yosofov, Noa Gabsi, Asaf Marco   +5 more
wiley   +1 more source

<i>In Vitro</i> and <i>In Vivo</i> Safety Evaluation of <i>Streptococcus salivarius</i> eK12, a Genetically Modified Dietary Probiotic Derived from the Oral Probiotic <i>S. salivarius</i> K12. [PDF]

J Microbiol Biotechnol
Di Pierro F, Veeraraghavan G, Kalaiselvan K, Ashif B, Jeyakumar L, Gopalakrishnan G, Cazzaniga M, Bertuccioli A, Tanda ML, Zerbinati N, Ujjan I, Bugti AA, Bano A, Gull Y, Mumtaz N, Khan A.   +15 more
europepmc   +1 more source

Effect of beneficial microbes applications on nutritional profiles of organic tomatoes revealed by LC‐MS‐qTOF metabolomics

Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2091-2099, 15 March 2026.
Abstract BACKGROUND The use of microorganisms and biostimulants is increasingly supported in agriculture because of their advantageous impact on plant disease management, growth enhancement and the synthesis of beneficial bioactive secondary metabolites (SMs). Tomato (Solanum lycopersicum) is an important crop and is consumed worldwide because it is an
Daria Lotito, Alessia Staropoli, Maria Isabella Prigigallo, Giuseppina Iacomino, Claudio Gigliotti, Giovanni Bubici, Sergio Bolletti‐Censi, Matteo Lorito, Francesco Vinale   +8 more
wiley   +1 more source

Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis. [PDF]

Arch Toxicol
Simon S, Schlingemann J, Johnson G, Brenneis C, Guessregen B, Kostal J, Dieckhoff J.   +6 more
europepmc   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data. [PDF]

Front Pharmacol
Ross A, Gombar V, Sedykh A, Green AJ, Borrel A, Kidd B, Phillips J, Shah M, Phadke D, Mav D, Balik-Meisner M, Howard B, Shah R, Kleinstreuer NC, Casey WM.   +14 more
europepmc   +1 more source

Mechanism and Molecular Design Principles of Cationic Surfactants: From Charge‐Driven Membrane Interactions to Next‐Generation Quaternary Ammonium Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Within this review we provide an overview of the social relevance of quaternary ammonium surfactants, different classes of these agents, their interaction mechanism with cellular membranes, structure activity relation, bacterial resistance toward these systems and new approaches to guarantee their long‐term efficiency.
Natalie Hanheiser, Yuhang Jiang, Chuanxiong Nie, Rainer Haag   +3 more
wiley   +1 more source