Results 221 to 230 of about 29,883 (310)

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood. [PDF]

Environ Mol Mutagen
Zhang X, Hobbs CA, Rivas MV, Diesing A, LeBlanc DPM, Zhou G, Foley JF, White PA, Marchetti F, Yauk CL, Smith-Roe SL.   +10 more
europepmc   +1 more source

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

Protein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source

Impact of <i>in vitro</i> digestion on the bioaccessibility, genotoxicity and mutagenicity of mycotoxins in a complex <i>Alternaria</i> extract. [PDF]

Food Chem X
Call F, Crudo F, Marko D.
europepmc   +1 more source

Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents

Pest Management Science, Volume 82, Issue 7, Page 6842-6863, July 2026.
A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos, Patricia V. Pietrantonio   +1 more
wiley   +1 more source

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology. [PDF]

Front Toxicol
Barutcu AR, Bhattarai N, Samuel R, Scaglione J, Recio L.   +4 more
europepmc   +1 more source

Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Enzyme assays and computational analyses reveal that human histidine methyltransferases SETD3 and METTL9 have a capacity to catalyze histidine ethylation in the presence of synthetic or in situ produced S‐adenosylethionine (AdoEth) and Se‐adenosylselenoethionine (AdoSeEth) cosubstrates.
Jordi C. J. Hintzen, Zhimei Yu, Sadaf Ahmad, Xin Zhang, Yuan–Yuan Zhao, Hao Deng, Leonie Schütz, Marija Ram, Julia Z. Kaminska, Jakub Drozak, Elmar Weinhold, Hong Guo, Andrea Rentmeister, Ping Qian, Jasmin Mecinović   +14 more
wiley   +1 more source

An asymptomatic <i>WASF1</i> truncation reveals pathogenic mechanism and therapeutic strategy for neurodevelopmental disorders. [PDF]

Front Behav Neurosci
Song S, Yang Z, Gao J, Wang X, Zhang Y, Wang J, Yang S, Chen J, Wang P.   +8 more
europepmc   +1 more source

Mutagenic Survey of Key Residues of NifB Involved in Radical SAM‐Dependent Nitrogenase Cofactor Assembly

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
NifB uses an RS–K1–K2 triad to assemble the L‐cluster, a [Fe8S9C] precursor of the nitrogenase cofactor. The RS module cleaves SAM to form the 5′‐dA radical, K1 serves structural/SAM‐sensing roles, and K2 drives radical‐dependent fusion with K1. SAM‐anchoring residues link SAM binding to cluster fusion, while termini and surface residues regulate ...
Calder Duffin, Robert Quechol, Yimo Yang, Chi Chung Lee, Yilin Hu, Markus W. Ribbe   +5 more
wiley   +1 more source

Extractables and Leachables in Pharmaceutical Products: Potential Adverse Effects and Toxicological Risk Assessment. [PDF]

Toxics
Kuzmič S, Zlobec T, Dolenc MS, Roškar R, Lušin TT.   +4 more
europepmc   +1 more source