Turmeric and curcumin: From traditional medicine to modern therapeutic applications
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem +7 more
wiley +1 more source
ChemBang: Expanding the Chemical Space Around Small Molecules
Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales +3 more
wiley +1 more source
Whole genome mutagenicity evaluation using Hawk-Seq™ demonstrates high inter-laboratory reproducibility and concordance with the transgenic rodent gene mutation assay. [PDF]
Matsumura S +16 more
europepmc +1 more source
ConforFold recovers alternative protein conformations beyond MSA subsampling
Abstract Conformational changes underlie many aspects of protein function, yet current structure prediction tools remain limited in their ability to systematically sample structural ensembles. Here, we present ConforPSSP and ConforFold, a combined framework that integrates secondary‐structure sampling into a deep learning‐based prediction to recover ...
Raulia Syrlybaeva, Eva‐Maria Strauch
wiley +1 more source
Integrating Adaptive Responses Into Hormesis: δ Plot Analysis of the Yonezawa Effect in the Micronucleus Test. [PDF]
Sutou S +5 more
europepmc +1 more source
ABSTRACT This review addresses the processing aspects and integrates in vitro and in vivo findings to highlight the various health benefits of indigenous fermented fish products from different regions of the world. Across Asia, Africa, and Northern Europe, fermented fish holds cultural significance, with each region boasting unique varieties shaped by ...
Banlambhabok Khongthaw +6 more
wiley +1 more source
In-silico assessment of phytochemical derivatives generated using CHEESE webserver for advancement of druggable candidate in pancreatic cancer therapy. [PDF]
Olowosoke CB +10 more
europepmc +1 more source
AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu +11 more
wiley +1 more source
Zinc diamyldithiocarbamate: MAK Value Documentation - Translation of the German version from 2023. [PDF]
Hartwig A, MAK Commission .
europepmc +1 more source
ABSTRACT Exposure to chemical pollutants can alter the rate and genome‐wide distribution of germline mutations. However, studies measuring the effects of chemical exposure on mutation rates and spectra have not considered the ecological and evolutionary backgrounds of the studied genotypes, which could influence the rates and patterns of germline ...
Nathan Keith +6 more
wiley +1 more source

