Results 231 to 240 of about 29,883 (310)

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
DNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
L. Peyton Russelburg, Merve Demir, Karina Cedeno, Sheila S. David, Martin P. Horvath   +4 more
wiley   +1 more source

The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives. [PDF]

Front Mol Biosci
Dang J, Liou JY, Mullah R, Giulivi C.
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Genotoxicity risk assessment of a 7-hydroxymitragynine-enriched Kratom preparation: An integrated in silico and in vitro approach. [PDF]

Toxicol Rep
Harnkit N, Sahad T, Noonate I, Primpai P, Radapong S, Pipatrattanaseree W, Sincharoenpokai P, Chamnanpuen P.   +7 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, Volume 600, Issue 11, Page 1638-1654, June 2026.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mutagenicity and Repair of Acrolein Adduct to Cytosine. [PDF]

Int J Mol Sci
Dylewska M, Kasperowicz S, Sokołowska B, Maciejewska AM.   +3 more
europepmc   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Synthesis, characterization, and biological activities of two new pyrazole Schiff base derivatives. [PDF]

Sci Rep
Matar S, Abu-Yamin AA, Taher D, Saraerah IAM, Salman M, Saghir SA, Ahmad F, Matar S, Buqa'en L, Elrashidi A.   +9 more
europepmc   +1 more source

Toward the Utilization of Char from the Hydrothermal Liquefaction of Polyethylene Plastic Waste: Studies of the Adsorption of Rhodamine B in an Aqueous Environment

Advanced Sustainable Systems, Volume 10, Issue 6, June 2026.
Hydrothermal liquefaction of waste polyethylene produces char that effectively removes rhodamine B from water. Nearly complete dye adsorption is achieved under optimum conditions, with adsorption following Langmuir isotherm and pseudo‐first‐order kinetics.
Himanshu Gupta, Shih‐Chieh Chien, Pankaj Verma, Paula Oulego, N. Raveendran Shiju   +4 more
wiley   +1 more source

Safety evaluation of pectin-rich extract derived from Coffea arabica as food additive. [PDF]

EFSA J
EFSA Panel on Food Additives and Flavourings (FAF), Castle L, Andreassen M, Aquilina G, Bastos ML, Boon P, Fallico B, FitzGerald R, Frutos Fernandez MJ, Grasl-Kraupp B, Gundert-Remy U, Gürtler R, Houdeau E, Kurek M, Louro H, Morales P, Passamonti S, Barat Baviera JM, Degen G, Gott D, Leblanc JC, Moldeus P, Waalkens-Berendsen I, Wölfle D, Mech A, Tard A, Zakidou P, Ruggeri L.   +27 more
europepmc   +1 more source