Results 61 to 70 of about 56,155 (258)
Angewandte Chemie International Edition, EarlyView.Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe +7 more
wiley +1 more source
Вісник Харківського Національного Університету Імені В.Н. Каразіна: Серія БіологіяThe article focuses on the assessment of the genotoxic potential of chemical compounds that may be released into the environment. The necessity of changing the basic vector of development of modern toxicology in view of the achievements in the field of ...
S.V. Kislyak +3 more
doaj +1 more source
Enzymes and Their Forms Used in Detection of Organophosphorus Compounds
Вестник войск РХБ защиты, 2021 Еnzymes are able to effectively interact with various organophosphorus compounds (OPC), entering into (bio)chemical reactions with them. Changes in the initial activity of enzymes as a result of their inhibition by OPC, the formation of OPC degradation ...
I. V. Lyagin, E. N. Efremenko
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Production of lotion using neem (Azadirachta Indica A. Juss) extract [PDF]
, 2020 Nowadays, the most emerging disease which is arthropod borne disease cannot be prevented from vaccines and become a potential threat especially in tropical world such as America, Africa and Asia and has become a trend (Al-Hashemi et al., 2016; Biswas et ...
Ghazali, Norliza +3 more
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Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Acta Scientiarum: Biological Sciences, 2017 The Brazilian semiarid region presents some adverse environmental conditions for the settled population such as a restricted water availability and the presence of radon and metal natural sources that can contaminate the water reservoirs and consequently
Richelly da Costa Dantas +5 more
doaj +1 more source
A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly [PDF]
, 2013 Zinc-finger nucleases (ZFNs) and TAL effector nucleases (TALENs) have been shown to induce targeted mutations, but they have not been extensively tested in any animal model. Here, we describe a large-scale comparison of ZFN and TALEN mutagenicity in
Antoshechkin, Igor +7 more
core +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes [PDF]
, 2014 The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present
Barrón-Vivanco, Briscia S. +9 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang +7 more
wiley +1 more source