Results 51 to 60 of about 29,926 (310)

An open source multistep model to predict mutagenicity from statistical analysis and relevant structural alerts

open access: yesChemistry Central Journal, 2010
Background Mutagenicity is the capability of a substance to cause genetic mutations. This property is of high public concern because it has a close relationship with carcinogenicity and potentially with reproductive toxicity. Experimentally, mutagenicity
Gini Giuseppina, Ferrari Thomas
doaj   +1 more source

Genotoxic and mutagenic effects of polluted surface water in the midwestern region of Brazil using animal and plant bioassays

open access: yesGenetics and Molecular Biology, 2016
This study aimed to evaluate DNA damage in animal and plant cells exposed to water from the Água Boa stream (Dourados, Mato Grosso do Sul, Brazil) by using bioassays, and to identify the chemical compounds in the water to determine the water quality in ...
Priscila Leocádia Rosa Dourado   +8 more
doaj   +1 more source

AEROSOL MUTAGENICITY IN SAN BERNARDINO, CALIFORNIA VIA BACTERIAL FLUCTUATION TESTS [PDF]

open access: yes, 2023
San Bernardino, California’s poor air quality is a health risk to its population with some of the highest concentrations of ozone and aerosol in the United States. Aerosols are solid or liquid particles suspended in the air. Smaller aerosol particles are
Murphy, Sean
core   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

open access: yesAdvanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena   +2 more
wiley   +1 more source

The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes

open access: yesBrazilian Archives of Biology and Technology, 2013
The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM).
Hasan Turkez, Elanur Aydin
doaj   +1 more source

Mutagenic and/or carcinogenic compounds in meat and meat products: Heterocyclic aromatic amines perspective

open access: yesТеория и практика переработки мяса, 2022
Meat and meat products, which have a very important place in terms of nutrition, can endanger human health if they are not properly prepared and preserved. Meat and meat products except for products such as sushi, which are deliberately consumed raw, are
E. Oz, F. Oz
doaj   +1 more source

Mutagenicity in a Molecule: Identification of Core Structural Features of Mutagenicity Using a Scaffold Analysis. [PDF]

open access: yes, 2016
With advances in the development and application of Ames mutagenicity in silico prediction tools, the International Conference on Harmonisation (ICH) has amended its M7 guideline to reflect the use of such prediction models for the detection of mutagenic
Olivia A. Lin (513420)   +9 more
core   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

A system for identification of structural markers of Ames mutagenicity based on similarity of xenobiotic structure fingerprints

open access: yesВісник Харківського Національного Університету Імені В.Н. Каразіна: Серія Біологія
The article focuses on the assessment of the genotoxic potential of chemical compounds that may be released into the environment. The necessity of changing the basic vector of development of modern toxicology in view of the achievements in the field of ...
S.V. Kislyak   +3 more
doaj   +1 more source

Potential hazard of simultaneous occurrence of aflatoxin B-1 and ochratoxin A

open access: yesVeterinární Medicína, 2001
Contents of aflatoxin B1 (AFB1) and ochratoxin A (OA) in the samples of wheat and barley were detected by RIA method. Average contents of AFB1 in the samples of wheat and barley were 2.4 µg/kg and 2.2 µg/kg, respectively.
M. Sedmíková   +4 more
doaj   +1 more source

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