Results 41 to 50 of about 29,883 (310)

An open source multistep model to predict mutagenicity from statistical analysis and relevant structural alerts

open access: yesChemistry Central Journal, 2010
Background Mutagenicity is the capability of a substance to cause genetic mutations. This property is of high public concern because it has a close relationship with carcinogenicity and potentially with reproductive toxicity. Experimentally, mutagenicity
Gini Giuseppina, Ferrari Thomas
doaj   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

open access: yesAdvanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei   +12 more
wiley   +1 more source

Genotoxic and mutagenic effects of polluted surface water in the midwestern region of Brazil using animal and plant bioassays

open access: yesGenetics and Molecular Biology, 2016
This study aimed to evaluate DNA damage in animal and plant cells exposed to water from the Água Boa stream (Dourados, Mato Grosso do Sul, Brazil) by using bioassays, and to identify the chemical compounds in the water to determine the water quality in ...
Priscila Leocádia Rosa Dourado   +8 more
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

open access: yesAdvanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao   +9 more
wiley   +1 more source

A system for identification of structural markers of Ames mutagenicity based on similarity of xenobiotic structure fingerprints

open access: yesВісник Харківського Національного Університету Імені В.Н. Каразіна: Серія Біологія
The article focuses on the assessment of the genotoxic potential of chemical compounds that may be released into the environment. The necessity of changing the basic vector of development of modern toxicology in view of the achievements in the field of ...
S.V. Kislyak   +3 more
doaj   +1 more source

The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes

open access: yesBrazilian Archives of Biology and Technology, 2013
The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM).
Hasan Turkez, Elanur Aydin
doaj   +1 more source

Mutagenic and/or carcinogenic compounds in meat and meat products: Heterocyclic aromatic amines perspective

open access: yesТеория и практика переработки мяса, 2022
Meat and meat products, which have a very important place in terms of nutrition, can endanger human health if they are not properly prepared and preserved. Meat and meat products except for products such as sushi, which are deliberately consumed raw, are
E. Oz, F. Oz
doaj   +1 more source

Mutagenicity of Hydrolyzed Proteins

open access: yes, 1998
The presence of 3-chloro-l, 2-propanediol (MCP) in hydrolyzed proteins (HPs) was reported, due to the reaction of excessive hydrochloric acid in the system with glycerine derived from neutral fat triglyceride.
渡辺, 悦生   +13 more
core   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

open access: yesAdvanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena   +2 more
wiley   +1 more source

Potential hazard of simultaneous occurrence of aflatoxin B-1 and ochratoxin A

open access: yesVeterinární Medicína, 2001
Contents of aflatoxin B1 (AFB1) and ochratoxin A (OA) in the samples of wheat and barley were detected by RIA method. Average contents of AFB1 in the samples of wheat and barley were 2.4 µg/kg and 2.2 µg/kg, respectively.
M. Sedmíková   +4 more
doaj   +1 more source

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