Results 111 to 120 of about 13,277,354 (332)

Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Serrated polyposis syndrome has been associated with an increased risk of colorectal cancer. HIC1 is a tumor suppressor gene commonly silenced in serrated polyps and several cancers. This study suggests HIC1 as a novel germline predisposition factor to serrated polyposis syndrome, with variants altering gene transcriptional regulation and ...
Xavier Domínguez‐Rovira   +24 more
wiley   +1 more source

Mass cytometric detection of homologous recombination proficiency in circulating tumor cells to predict chemoresistance of metastatic breast cancer patients

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Circulating tumor cells can offer insights into treatment responses and metastatic recurrence, but current analysis methods are limited. Here, the authors tested a newly developed mass cytometry panel comprising biomarkers such as γH2AX and RAD51 in longitudinally monitored metastatic breast cancer patients.
Kathrin Niedermayer   +17 more
wiley   +1 more source

Evaluating the Genotoxicity and Mutagenicity of Food Contaminants: Acrylamide, Penitrem A, and 3‐Acetyldeoxynivalenol in Individual and Combined Exposure In Vitro

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate the genotoxic effects of food contaminants exposure in human neuroblastoma SH‐SY5Y cells using the micronucleus (MN) assay and Ames test. Acrylamide (AA), penitrem A (PEN A), and 3‐acetyldeoxynivalenol (3‐ADON) were tested both individually and in combination.
Luna Bridgeman   +4 more
wiley   +1 more source

Characterization of mutagenic principles and carcinogenicity test of dill weed and seeds.

open access: bronze, 1980
Masamichi Fukuoka   +6 more
openalex   +2 more sources

Do Gadolinium‐Based Contrasts Represent a High Risk for Genotoxicity in Mammalian Cells? A Systematic Review

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The scientific rationale for this review stems from the increasing global use of gadolinium‐based contrast agents in medical imaging and the concerns over the long‐term environmental accumulation of gadolinium waste, which may pose biological risks.
Thiago Guedes Pinto   +2 more
wiley   +1 more source

Environmental Effects of Volcanic Volatile Fluxes From Subaerial Large Igneous Provinces

open access: yesGeophysical Monograph Series, Page 103-116., 2021

Exploring the links between Large Igneous Provinces and dramatic environmental impact

An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Tamsin A. Mather, Anja Schmidt
wiley  

+1 more source

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