Results 131 to 140 of about 10,959 (312)

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

Phytotherapy Research, EarlyView.
ABSTRACT Over the last decade, ashwagandha (Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler, R. Al‐Mondhiry, L. Lang, R. Marles, M. Tallon, A. Raghu   +5 more
wiley   +1 more source

Mutagenicity of acrylonitrile.

, 1978
Incubation of Salmonella typhimurium strains in an atmosphere of 0.2% gaseous acrylonitrile increased the numbers of his+ revertants/plate only in the presence of a fortified S9 liver fraction.
De Meester, Conrad, Roberfroid, Marcel, Mercier, Michel, Poncelet, F.   +3 more
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Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity.

, 2013
Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on 31 their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for rel- 32 evant toxicological endpoints to avoid
Rorije, E., Buist, H., Schüürmann, G., Escher, S., Aldenberg, T., Pauné, E., Batke, M., Kroese, D.E., Kühne, R., Marquart, H.   +9 more
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Nanosilica coating for bonding improvements to zirconia

International Journal of Nanomedicine, 2013
Chen Chen, Gang Chen, Haifeng Xie, Wenyong Dai, Feimin Zhang Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China Abstract: Resin bonding to zirconia cannot be established from standard methods ...
Chen C, Chen G, Xie H, Dai W, Zhang F
doaj  

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

The Employment of Hydrogen Peroxide in Water Disinfection Poses a Threat to Aquatic Ecosystems Because of Its Toxicity to Nontarget Organisms

Environmental Toxicology, EarlyView.
ABSTRACT Hydrogen peroxide is widely used in water and wastewater treatment, particularly in advanced oxidation processes that aid in the degradation of compounds and microbial disinfection. Despite concerns about potential environmental contamination, its impact on freshwater ecosystems remains inadequately studied.
Letícia Queiroz Almeida, Thayrine Dias Carlos, Leydiane Barbosa Bezerra, Rone S. Barbosa, Nelson Luís Gonçalves Dias Souza, Douglas Henrique Pereira, Renato Almeida Sarmento, Grasiele Soares Cavallini   +7 more
wiley   +1 more source

Mutagenicity and Anticholinesterase Activity of Some Possible Metabolites of Aryl N-Methylcarbamates

Some possible metabolites of carbaryl including demethyl, hydroxymethyl, N-hydroxy, and N-nitroso derivatives and of phenyl N-methylcarbamate were examined for mutagenicity using the mutants of Salmonella typhimurium (Ames test) and B a - cillus subtilis
Eto, morifusa, 上畠, 真里子, 中津, 誠一郎, 江藤, 守総, 水光, 正仁, Nakatsu, Seiichiro, Yoshikawa, Mitsuko, Kohno, Mitsuko, Kamihata, Mariko, Kuwano, Eiichi, 桑野, 栄一, Suiko, Masahito   +11 more
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