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SAR Modeling to Predict Ames Mutagenicity Across Different <i>Salmonella typhimurium</i> Strains. [PDF]

open access: yesPharmaceuticals (Basel)
Dmitriev AV   +6 more
europepmc   +1 more source
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Mutagenicity tests with griseofulvin

Mutation Research/Genetic Toxicology, 1979
Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse. It was also tested for its capacity to produce his+ revertants in Salmonella typhimurium. All tests yielded negative results, whereas highly significant effects were recorded in control assays with thio-TEPA.
Leonard, A   +4 more
openaire   +2 more sources

Mutagenicity testing in industry

Archives of Toxicology, 1977
The aims of authorities, university and industrial scientists are outlined. The prime feature remains: How important are the achieved results for estimating the mutagenic risk to humans? The various methods available for the testing of chemical substances for mutagenicity are compared.
openaire   +2 more sources

Mutagenicity testing with Salmonella microsome test

Archives of Toxicology, 1980
This in vitro mutagenicity test system comprises five different strains of S. typhimurium as target cells with the rat liver S-9 fraction and appropriate co-factors for metabolic activation of the chemical tested. The bacterial tester strains detect both mutations induced by base pair substitutions and intercalation (frame shift mutations).
Greim, H.A.   +3 more
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A Test for Mutagenicity of Methylcholanthrene

Nature, 1948
RECENT results by Strong1,2 and by Carr3 on mice, and by Demerec4 on Drosophila, have focused interest on a possible connexion between mutagenicity and carcinogenicity, which in the past has often been claimed on theoretical grounds. While Auerbach5 failed to produce mutations by injection of 1 : 2 : 5 : 6 dibenzanthracene into Drosophila, Demerec ...
openaire   +2 more sources

Mutagen Testing with Yeast

1985
This article deals primarily with the practical aspects of mutagen testing with yeast. Equipment necessary for a laboratory where mutagen testing with yeast is performed, and the most commonly used media, are listed. Some general procedures are described and, finally, for those who have little experience with work of this kind, a precise protocol is ...
F, Eckardt, W, Siede
openaire   +2 more sources

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